Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms.

Aged Amino Acid Substitution Blast Crisis/genetics,mortality Cohort Studies DNA, Neoplasm/genetics DNA-Binding Proteins/genetics Dioxygenases Enhancer of Zeste Homolog 2 Protein Exons/genetics Female Genotype Germ-Line Mutation Humans Leukemia, Myelomonocytic, Chronic/genetics,mortality Male Mutation, Missense Myeloproliferative Disorders/genetics,mortality,pathology Neoplasm Proteins/genetics Polycomb Repressive Complex 2 Polymorphism, Single Nucleotide Primary Myelofibrosis/genetics,mortality Prognosis Proto-Oncogene Proteins/genetics Repressor Proteins/genetics Sequence Analysis, DNA Transcription Factors/genetics

ASXL1 protein, human DNA, Neoplasm DNA-Binding Proteins Neoplasm Proteins Proto-Oncogene Proteins Repressor Proteins Transcription Factors Dioxygenases TET2 protein, human EZH2 protein, human Enhancer of Zeste Homolog 2 Protein Polycomb Repressive Complex 2