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PMID: 21512418 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Homocysteine effects on brain volumes mapped in 732 elderly individuals.

Neuroreport ·Vol. 22 ·No. 8 ·2011-06-11 ·Pages 391-5

Rajagopalan P, Hua X, Toga AW, Jack CR, Weiner MW, Thompson PM

Abstract

Elevated homocysteine levels are a known risk factor for Alzheimer's disease and vascular disorders. Here we applied tensor-based morphometry to brain magnetic resonance imaging scans of 732 elderly individuals from the Alzheimer's Disease Neuroimaging Initiative study, to determine associations between homocysteine and brain atrophy. Those with higher homocysteine levels showed greater frontal, parietal, and occipital white matter atrophy in the entire cohort, irrespective of diagnosis, age, or sex. This association was also found when considering mild cognitive impairment individuals separately. Vitamin B supplements, such as folate, may help prevent homocysteine-related atrophy in Alzheimer's disease by possibly reducing homocysteine levels. These atrophy profiles may, in the future, offer a potential biomarker to gauge the efficacy of interventions using dietary folate supplementation.

MeSH Terms
Aged Alzheimer Disease/blood,pathology Brain/pathology Brain Mapping Cognition Disorders/blood,pathology Enzyme-Linked Immunosorbent Assay Female Homocysteine/blood Humans Image Interpretation, Computer-Assisted Magnetic Resonance Imaging Male
Chemicals
Homocysteine
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Rajagopalan Priya
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095-7332, USA.
Hua Xue
Toga Arthur W
Jack Clifford R
Weiner Michael W
Thompson Paul M
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Article Info
Journal
Neuroreport
Abbr.
Neuroreport
ISSN
1473-558X
DOI
10.1097/WNR.0b013e328346bf85
Published
2011-06-11
Pages
391-5
Language
English
Region
England
NLM ID
9100935
PMCID
PMC3192851
Subset
IM
Grants
NIA NIH HHS · K01 AG030514 · United States
NIA NIH HHS · K01 AG030514-05 · United States
NIBIB NIH HHS · R01 EB008281-14 · United States
NIA NIH HHS · R01 AG020098-09 · United States
NIA NIH HHS · P30 AG010129 · United States
NIA NIH HHS · P30 AG010129-20 · United States
NIBIB NIH HHS · R01 EB008281 · United States
NIA NIH HHS · U01 AG024904 · United States
NIA NIH HHS · U19 AG010483 · United States
NIA NIH HHS · U01 AG024904-07 · United States
NIA NIH HHS · R01 AG020098 · United States
External Links
PubMed source DOI: 10.1097/WNR.0b013e328346bf85 PMC Full Text View journal details
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