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PMID: 21527828 Published · ppublish English Journal Article Review

FANCP/SLX4: a Swiss army knife of DNA interstrand crosslink repair.

Cell cycle (Georgetown, Tex.) ·Vol. 10 ·No. 11 ·2011-06-01 ·Pages 1757-63

Cybulski KE, Howlett NG

Abstract

Fanconi anemia (FA) is a rare genetic disease characterized by congenital abnormalities, bone marrow failure and heightened cancer susceptibility. The FA proteins are known to function in the cellular defense against DNA interstrand crosslinks (ICLs), a process that remains poorly understood. A recent spate of discoveries has led to the identification of one new FA gene, FANCP/SLX4, and two strong candidate FA genes, FAN1 and RAD51C. In this perspective we describe the discovery of FANCP/SLX4 and discuss how these new findings collectively refine our understanding of DNA ICL repair.

MeSH Terms
DNA Repair Fanconi Anemia/genetics Fanconi Anemia Complementation Group Proteins/genetics Humans Recombinases/genetics
Chemicals
Fanconi Anemia Complementation Group Proteins Recombinases SLX4 protein, human
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cybulski Kelly E
University of Rhode Island, Kingston, RI, USA.
Howlett Niall G
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Article Info
Journal
Cell cycle (Georgetown, Tex.)
Abbr.
Cell Cycle
ISSN
1551-4005
DOI
10.4161/cc.10.11.15818
Published
2011-06-01
Epub
2011-00-01
Pages
1757-63
Language
English
Region
United States
NLM ID
101137841
PMCID
PMC3142459
Subset
IM
Grants
NHLBI NIH HHS · R01 HL101977 · United States
External Links
PubMed source DOI: 10.4161/cc.10.11.15818 PMC Full Text View journal details
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