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PMID: 2153573 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Effects of pertussis toxin on alpha 1-agonist-mediated phosphatidylinositide turnover and myocardial cell hypertrophy in neonatal rat ventricular myocytes.

Experientia ·Vol. 46 ·No. 1 ·1990-01-15 ·Pages 81-4

Karliner JS, Kagiya T, Simpson PC

Abstract

In neonatal rat ventricular myocytes pretreatment with pertussis toxin did not affect 1 microM (-)-norepinephrine stimulation of inositol phosphates or myocardial cell hypertrophy as measured either by protein radiolabelling or by myocardial cell protein content. Thus guanine nucleotide protein(s) ADP-ribosylated by pertussis toxin do not play a role in two alpha 1-adrenoceptor-mediated processes, phosphatidylinositide turnover and induction of myocardial cell hypertrophy.

MeSH Terms
Adenosine Diphosphate Ribose/metabolism Animals Animals, Newborn/metabolism Cell Division Cells, Cultured Inositol Phosphates/metabolism Myocardium/cytology,metabolism Norepinephrine/pharmacology Pertussis Toxin Phosphatidylinositols/metabolism Prazosin/analogs & derivatives,pharmacology Propranolol/pharmacology Rats Receptors, Adrenergic, alpha/physiology Virulence Factors, Bordetella/pharmacology Yohimbine/pharmacology
Chemicals
Inositol Phosphates Phosphatidylinositols Receptors, Adrenergic, alpha Virulence Factors, Bordetella Adenosine Diphosphate Ribose Yohimbine Terazosin Propranolol Pertussis Toxin Norepinephrine Prazosin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Karliner J S
Cardiology Section (III C), Veterans Administratin Medical Center, San Francisco, California 94121.
Kagiya T
Simpson P C
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Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01955423
Published
1990-01-15
Pages
81-4
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
Grants
NHLBI NIH HHS · R01 HL031113 · United States
NHLBI NIH HHS · HL31113 · United States
External Links
PubMed source DOI: 10.1007/BF01955423
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