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PMID: 2154740 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A dual laminin/collagen receptor acts in peripheral nerve regeneration.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 87 ·No. 4 ·1990-02-00 ·Pages 1319-22

Toyota B, Carbonetto S, David S

Abstract

A regeneration chamber was created in vivo by suturing a synthetic tube sealed at its distal end onto the proximal stump of a severed rat sciatic nerve. Nerves regenerated into tubes coated with laminin at a rate of 0.33 mm/day after a lag of about 2 days. At 25 days, regenerating nerves had extended 23% farther into laminin-coated tubes as compared with uncoated ones. Monoclonal antibody 3A3, which functionally interferes with a dual laminin/collagen receptor, inhibited nerve regeneration into laminin-coated tubes by 32%. In contrast, monoclonal antibody JG22, which inhibits chicken matrix receptors, had no significant effect on regeneration. Immunohistochemical studies of teased adult rat sciatic nerves indicate that 3A3 bound to Schwann cells and possibly to axons. In other studies, the heterodimeric, laminin/collagen receptor recognized by 3A3 has been shown to be a member of the integrin superfamily of adhesive receptors. These data provide evidence that an integrin receptor functions in nerve regeneration in vivo.

MeSH Terms
Animals Antibodies, Monoclonal Axons/physiology Cells, Cultured Chick Embryo Collagen/physiology Female Ganglia, Spinal/physiology Kinetics Laminin/physiology Nerve Regeneration Rats Rats, Inbred Strains Receptors, Cell Surface/physiology Receptors, Collagen Receptors, Immunologic/physiology Receptors, Laminin Sciatic Nerve/physiology Time Factors
Chemicals
Antibodies, Monoclonal Laminin Receptors, Cell Surface Receptors, Collagen Receptors, Immunologic Receptors, Laminin Collagen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Toyota B
Centre for Research in Neuroscience, McGill University, Montreal General Hospital Research Institute, PQ, Canada.
Carbonetto S
David S
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46 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.87.4.1319
Published
1990-02-00
Pages
1319-22
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC53466
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.87.4.1319 PMC Full Text View journal details
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