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PMID: 2156259 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 87 ·No. 6 ·1990-03-00 ·Pages 2057-61

Miller RH, Purcell RH

Abstract

Hepatitis C virus (HCV) is an important human pathogen that is associated with transfusion-related non-A, non-B hepatitis. Recently, HCV cDNA was cloned and the nucleotide sequence of approximately three-quarters of the virus genome was determined. A region of the predicted polyprotein sequence was found to share similarity with a nonstructural protein encoded by dengue virus, a member of the flavivirus family. We report here that HCV shares an even greater degree of protein sequence similarity with members of the pestivirus group (i.e., bovine viral diarrhea virus and hog cholera virus), which are thought to be distantly related to the flaviviruses. In addition, we find that HCV shares significant protein sequence similarity with the polyproteins encoded by members of the picornavirus-like and alphavirus-like plant virus supergroups. These data suggest that HCV may be evolutionarily related to both plant and animal viruses.

MeSH Terms
Amino Acid Sequence Flavivirus/genetics Hepatitis Viruses/genetics Information Systems Molecular Sequence Data Pestivirus/genetics Sequence Homology, Nucleic Acid Software Species Specificity
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Miller R H
Hepatitis Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Purcell R H
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.87.6.2057
Published
1990-03-00
Pages
2057-61
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC53625
Subset
IM
Grants
PHS HHS · U41-01685-05 · United States
External Links
PubMed source DOI: 10.1073/pnas.87.6.2057 PMC Full Text View journal details
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