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PMID: 2158158 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Okadaic acid: a new probe for the study of cellular regulation.

Trends in biochemical sciences ·Vol. 15 ·No. 3 ·1990-03-00 ·Pages 98-102

Cohen P, Holmes CF, Tsukitani Y

Abstract

The tumour promoter okadaic acid is a potent and specific inhibitor of protein phosphatases 1 and 2A. Here we review recent studies which demonstrate that this toxin is extremely useful for identifying biological processes that are controlled through the reversible phosphorylation of proteins.

MeSH Terms
Animals Carcinogens Cell Extracts Cells/drug effects Diarrhea/etiology Ethers, Cyclic/metabolism,pharmacology,toxicity Humans Marine Toxins Okadaic Acid Oxazoles/pharmacology,toxicity Phosphoprotein Phosphatases/analysis,antagonists & inhibitors Phosphorylation Shellfish Poisoning
Chemicals
Carcinogens Cell Extracts Ethers, Cyclic Marine Toxins Oxazoles Okadaic Acid calyculin A Phosphoprotein Phosphatases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Cohen P
Department of Biochemistry, University of Dundee, UK.
Holmes C F
Tsukitani Y
Article Info
Journal
Trends in biochemical sciences
Abbr.
Trends Biochem Sci
ISSN
0968-0004
DOI
10.1016/0968-0004(90)90192-e
Published
1990-03-00
Pages
98-102
Language
English
Region
England
NLM ID
7610674
Subset
IM
External Links
PubMed source DOI: 10.1016/0968-0004(90)90192-e View journal details
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