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PMID: 2159257 Published · ppublish English Comparative Study Journal Article

Evaluation of Bay R 3783 in rodent models of superficial and systemic candidiasis, meningeal cryptococcosis, and pulmonary aspergillosis.

Antimicrobial agents and chemotherapy ·Vol. 34 ·No. 3 ·1990-03-00 ·Pages 448-54

Hector RF, Yee E

Abstract

The triazole Bay R 3783 was compared with fluconazole, itraconazole, ketoconazole, and amphotericin B in rodent models of superficial and systemic candidiasis, meningocerebral cryptococcosis, and pulmonary aspergillosis. Overall, Bay R 3783 was comparable or slightly superior to fluconazole and markedly superior to itraconazole and ketoconazole in both survival and short-term organ load experiments in models of candidiasis and cryptococcosis but was less effective than amphotericin B. Of the antifungal agents tested, only Bay R 3783 and itraconazole showed any efficacy in the model of pulmonary aspergillosis.

MeSH Terms
Administration, Oral Amphotericin B/pharmacology Animals Antifungal Agents/pharmacology Aspergillosis/drug therapy Candidiasis/drug therapy Cryptococcosis/drug therapy Disease Models, Animal Drug Administration Schedule Evaluation Studies as Topic Female Fluconazole/pharmacology Itraconazole Ketoconazole/analogs & derivatives,pharmacology Lung Diseases, Fungal/drug therapy Male Meningitis/drug therapy Mice Pharmaceutical Vehicles Rats Rats, Inbred Strains Triazoles/pharmacology,therapeutic use
Chemicals
Antifungal Agents Pharmaceutical Vehicles Triazoles Bay R 3783 Itraconazole Amphotericin B Fluconazole Ketoconazole
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hector R F
Cutter Biological, Berkeley, California 94710.
Yee E
References (34)
34 references, click to expand
  1. Inhibition of sterol biosynthesis in Candida albicans by imidazole-containing antifungals.
    J Gen Microbiol. 1980 Mar;117(1):253-5 PMID: 6993625
  2. Fluconazole penetration into cerebrospinal fluid in humans.
    J Clin Pharmacol. 1988 Apr;28(4):363-6 PMID: 2839557
  3. Bifonazole and clotrimazole. Their mode of action and the possible reason for the fungicidal behaviour of bifonazole.
    Arzneimittelforschung. 1984;34(2):139-46 PMID: 6372801
  4. Comparison of itraconazole and ketoconazole in the treatment of experimental candidal vaginitis.
    Antimicrob Agents Chemother. 1984 Aug;26(2):266-7 PMID: 6091538
  5. R 51211 (itraconazole) therapy of murine cryptococcosis.
    Sabouraudia. 1984;22(6):445-53 PMID: 6098031
  6. Itraconazole treatment of murine aspergillosis.
    Sabouraudia. 1985 Jun;23(3):219-23 PMID: 2992106
  7. Efficacy of UK-49,858 (fluconazole) against Candida albicans experimental infections in mice.
    Antimicrob Agents Chemother. 1985 Dec;28(6):815-8 PMID: 3002246
  8. Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits.
    Antimicrob Agents Chemother. 1986 Apr;29(4):579-83 PMID: 3010846
  9. Treatment of cryptococcal meningitis in mice with fluconazole.
    J Antimicrob Chemother. 1986 Aug;18(2):261-70 PMID: 3019986
  10. Itraconazole pharmacokinetics in the female genital tract: plasma and tissue levels in patients undergoing hysterectomy after a single dose of 200 mg itraconazole.
    Eur J Obstet Gynecol Reprod Biol. 1986 Oct;23(1-2):85-9 PMID: 3023155
  11. Itraconazole in the treatment of human mycoses: review of three years of clinical experience.
    Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S146-52 PMID: 3027842
  12. Itraconazole: pharmacologic studies in animals and humans.
    Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S43-6 PMID: 3027845
  13. Fluconazole and testosterone: in vivo and in vitro studies.
    Antimicrob Agents Chemother. 1988 May;32(5):646-8 PMID: 2840013
  14. Oral fluconazole therapy for patients with acquired immunodeficiency syndrome and cryptococcosis: experience with 22 patients.
    Am J Med. 1988 Oct;85(4):477-80 PMID: 2845778
  15. Oral fluconazole as suppressive therapy of disseminated cryptococcosis in patients with acquired immunodeficiency syndrome.
    Am J Med. 1988 Oct;85(4):481-9 PMID: 2845779
  16. The epidemiology of AIDS in the U.S.
    Sci Am. 1988 Oct;259(4):72-81 PMID: 3072674
  17. Comparison of the efficacies of amphotericin B, fluconazole, and itraconazole against a systemic Candida albicans infection in normal and neutropenic mice.
    Antimicrob Agents Chemother. 1989 Feb;33(2):147-51 PMID: 2541654
  18. Oral treatment of paracoccidioidomycosis and histoplasmosis with itraconazole in humans.
    Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S47-50 PMID: 3027846
  19. Itraconazole in the treatment of paracoccidioidomycosis: a preliminary report.
    Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S51-6 PMID: 3027847
  20. A clinical trial of itraconazole in the treatment of deep mycoses and leishmaniasis.
    Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S57-63 PMID: 3027848
  21. Early experience with itraconazole in vitro and in patients: pharmacokinetic studies and clinical results.
    Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S71-6 PMID: 3027850
  22. Initial experience in therapy for progressive mycoses with itraconazole, the first clinically studied triazole.
    Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S77-86 PMID: 3027851
  23. Itraconazole treatment of experimental systemic candidiasis in male rats.
    J Med Vet Mycol. 1987 Apr;25(2):125-6 PMID: 3037058
  24. Adrenal response to corticotropin during therapy with itraconazole.
    Antimicrob Agents Chemother. 1987 Apr;31(4):647-9 PMID: 3038002
  25. Fluconazole penetration into cerebrospinal fluid: implications for treating fungal infections of the central nervous system.
    J Infect Dis. 1988 Jan;157(1):178-80 PMID: 2826606
  26. A comparison of the efficacy of itraconazole, amphotericin B and 5-fluorocytosine in the treatment of Aspergillus fumigatus endocarditis in the rabbit.
    J Antimicrob Chemother. 1987 Nov;20(5):719-24 PMID: 2828301
  27. Itraconazole in the treatment of acute vaginal candidiasis.
    S Afr Med J. 1988 Feb 6;73(3):172-3 PMID: 2829371
  28. Itraconazole as maintenance treatment for cryptococcal meningitis in the acquired immune deficiency syndrome.
    Br Med J (Clin Res Ed). 1988 Jan 30;296(6618):339 PMID: 2830934
  29. Pharmacokinetic profile of orally administered itraconazole in human skin.
    J Am Acad Dermatol. 1988 Feb;18(2 Pt 1):263-8 PMID: 2831254
  30. Cryptococcal meningitis in patients with AIDS.
    J Infect Dis. 1988 Apr;157(4):624-8 PMID: 3279135
  31. Recent advances in the treatment of systemic fungal infections.
    Methods Find Exp Clin Pharmacol. 1987 Nov;9(11):769-78 PMID: 2834615
  32. Activities of fluconazole (UK 49,858) and ketoconazole against ketoconazole-susceptible and -resistant Candida albicans.
    Antimicrob Agents Chemother. 1988 Feb;32(2):209-12 PMID: 2834995
  33. Pharmacokinetics of fluconazole in cerebrospinal fluid and serum in human coccidioidal meningitis.
    Antimicrob Agents Chemother. 1988 Mar;32(3):369-73 PMID: 2835002
  34. Mammary gland contamination as a means of establishing long-term gastrointestinal colonization of infant mice with Candida albicans.
    Infect Immun. 1982 Nov;38(2):788-90 PMID: 6754622
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.34.3.448
Published
1990-03-00
Pages
448-54
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC171613
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.34.3.448 PMC Full Text View journal details
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