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PMID: 21624447 Published · ppublish English Journal Article

Drawdown of floating solids in stirred tanks: scale-up study using CFD modeling.

International journal of pharmaceutics ·Vol. 418 ·No. 2 ·2011-10-14 ·页码 243-53

Waghmare Y, Falk R, Graham L, Koganti V

Abstract

This work shows development of a scale up correlation using computational fluid dynamic (CFD) simulations for floating solids drawdown operation in stirred tanks. Discrete phase modeling (DPM) simulations were used in conjunction with the lab scale experimental measurements to develop a semi-empirical correlation for the prediction of rate of drawdown of floating solid particles. The rate was correlated to average liquid velocity at the free liquid surface. Since, this correlation is based on a fundamental hydrodynamic parameter, velocity, rather than an operating parameters such as the impeller speed, it can be used for a variety of impeller types and tank geometries. The correlation was developed based on the data obtained from the 2L tank using four different tank designs and was validated against the data obtained from the 10L scale tank. The correlation was further extended to the pilot and the commercial scale tanks ranging from 40L to 4000L scale based solely on the CFD model.

MeSH 主题词
Computer Simulation Drug Compounding/methods Pharmaceutical Preparations/chemistry Reproducibility of Results
化学物质
Pharmaceutical Preparations
作者与单位
共 4 位作者,点击展开单位 / ORCID
Waghmare Yogesh
Bend Research Inc., 64550 Research Rd., Bend, OR 97701, United States. [email protected]
Falk Rick
Graham Lisa
Koganti Venkat
Article Info
Journal
International journal of pharmaceutics
Abbr.
Int J Pharm
ISSN
1873-3476
Corresponding email
Published
2011-10-14
电子出版
2011-00-20
页码
243-53
Language
English
Country/Region
Netherlands
NLM ID
7804127
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