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PMID: 21633387 Published · epublish English Review

Cubism and the cell cycle: the many faces of the APC/C.

Nature reviews. Molecular cell biology ·Vol. 12 ·No. 7 ·2011-00-02 ·Pages 427-38

Pines J

Abstract

One does not often look to analytic cubism for insights into the control of the cell cycle, but Pablo Picasso beautifully encapsulated the fundamentals when he said that "every act of creation is, first of all, an act of destruction". The rapid destruction of specific cell cycle regulators at just the right moment in the cell cycle ensures that daughter cells receive an equal and identical set of chromosomes from their mother and that DNA replication always follows mitosis. Remarkably, one protein complex is responsible for this surgical precision, the APC/C (anaphase-promoting complex, also known as the cyclosome). The APC/C is tightly regulated by its co-activators and by the spindle assembly checkpoint.

MeSH Terms
Anaphase-Promoting Complex-Cyclosome Animals Cell Cycle/physiology Cell Cycle Proteins/metabolism Humans Mitosis/physiology Models, Biological Spindle Apparatus/metabolism Ubiquitin-Protein Ligase Complexes/metabolism
Chemicals
Cell Cycle Proteins Ubiquitin-Protein Ligase Complexes Anaphase-Promoting Complex-Cyclosome
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Pines Jonathon
The Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK. [email protected]
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm3132
Email
[email protected]
Published
2011-00-02
Epub
2011-00-02
Pages
427-38
Language
English
Region
England
NLM ID
100962782
Subset
IM
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1038/nrm3132 View journal details
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