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PMID: 21641544 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Fine tuning our cellular factories: sirtuins in mitochondrial biology.

Cell metabolism ·Vol. 13 ·No. 6 ·2011-06-08 ·Pages 621-6

Zhong L, Mostoslavsky R

Abstract

Sirtuins have emerged in recent years as critical regulators of metabolism, influencing numerous facets of energy and nutrient homeostasis. Here, we review recent advances on the role of this fascinating family of mammalian proteins and their well-orchestrated function in modulating mitochondrial activity.

MeSH Terms
Acetates/metabolism Animals Apoptosis Citric Acid Cycle Electron Transport Glycolysis Humans Insulin/metabolism Lipid Metabolism Liver/metabolism Mitochondria/metabolism Muscle, Skeletal/metabolism Oxidative Stress Signal Transduction Sirtuins/metabolism
Chemicals
Acetates Insulin Sirtuins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Zhong Lei
The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.
Mostoslavsky Raul
References (28)
28 references, click to expand
  1. SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells.
    J Biol Chem. 2010 Oct 15;285(42):31995-2002 PMID: 20685656
  2. Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.
    Trends Biochem Sci. 2010 Dec;35(12):669-75 PMID: 20863707
  3. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.
    Cell Metab. 2010 Dec 1;12(6):654-61 PMID: 21109197
  4. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.
    Cell. 2009 May 1;137(3):560-70 PMID: 19410549
  5. Recent progress in the biology and physiology of sirtuins.
    Nature. 2009 Jul 30;460(7255):587-91 PMID: 19641587
  6. SIRT3 substrate specificity determined by peptide arrays and machine learning.
    ACS Chem Biol. 2011 Feb 18;6(2):146-57 PMID: 20945913
  7. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation.
    Cell Metab. 2010 Dec 1;12(6):662-7 PMID: 21109198
  8. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha.
    Mol Cell. 2010 Jun 25;38(6):864-78 PMID: 20620956
  9. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.
    Cell. 2010 Jan 22;140(2):280-93 PMID: 20141841
  10. Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure.
    J Biol Chem. 2010 Mar 12;285(11):8375-82 PMID: 20089851
  11. Sirtuins regulate key aspects of lipid metabolism.
    Biochim Biophys Acta. 2010 Aug;1804(8):1652-7 PMID: 19962456
  12. Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases.
    Trends Pharmacol Sci. 2010 May;31(5):212-20 PMID: 20226541
  13. Insulin signaling meets mitochondria in metabolism.
    Trends Endocrinol Metab. 2010 Oct;21(10):589-98 PMID: 20638297
  14. Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3.
    J Cell Sci. 2010 Dec 1;123(Pt 23):4117-27 PMID: 21062897
  15. Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney.
    J Clin Invest. 2010 Apr;120(4):1043-55 PMID: 20335657
  16. SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization.
    Cancer Cell. 2011 Mar 8;19(3):416-28 PMID: 21397863
  17. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction.
    Mol Cell. 2011 Jan 21;41(2):139-49 PMID: 21255725
  18. Calorie restriction alters mitochondrial protein acetylation.
    Aging Cell. 2009 Sep;8(5):604-6 PMID: 19594485
  19. Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis.
    J Biol Chem. 2010 Jul 9;285(28):21590-9 PMID: 20448046
  20. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.
    Cell. 2010 Nov 24;143(5):802-12 PMID: 21094524
  21. Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism.
    J Biol Chem. 2011 Feb 25;286(8):6049-60 PMID: 21163946
  22. SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70.
    Mol Cell Biol. 2008 Oct;28(20):6384-401 PMID: 18710944
  23. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.
    Genes Dev. 1999 Oct 1;13(19):2570-80 PMID: 10521401
  24. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy.
    Aging (Albany NY). 2010 Dec;2(12):914-23 PMID: 21212461
  25. Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria.
    Biochemistry. 2010 Jan 19;49(2):304-11 PMID: 20000467
  26. Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.
    Cell Metab. 2010 Sep 8;12(3):224-36 PMID: 20816089
  27. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.
    Mol Cell. 2010 Dec 22;40(6):893-904 PMID: 21172655
  28. On the origin of cancer cells.
    Science. 1956 Feb 24;123(3191):309-14 PMID: 13298683
Article Info
Journal
Cell metabolism
Abbr.
Cell Metab
ISSN
1932-7420
DOI
10.1016/j.cmet.2011.05.004
Published
2011-06-08
Pages
621-6
Language
English
Region
United States
NLM ID
101233170
PMCID
PMC3111451
Subset
IM
Grants
NIGMS NIH HHS · R01 GM093072-01 · United States
NIDDK NIH HHS · R01 DK088190 · United States
NIDDK NIH HHS · R01DK088190-01A1 · United States
NIDDK NIH HHS · R01 DK088190-01A1 · United States
NIGMS NIH HHS · R01 GM093072 · United States
NIGMS NIH HHS · R01GM093072-01 · United States
External Links
PubMed source DOI: 10.1016/j.cmet.2011.05.004 PMC Full Text View journal details
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