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PMID: 21658598 Published · ppublish English Comment Journal Article

A SirT'N repression for Notch.

Molecular cell ·Vol. 42 ·No. 5 ·2011-06-10 ·Pages 559-60

Jones KA

Abstract

Mulligan et al. (2011) show here that the NAD(+)-dependent SIRT1 (H4K16; H1K26) deacetylase acts in concert with the LSD1 (H3K4) demethylase to repress Notch-induced transcription, thus coupling two distinct histone modifications at a key epigenetic switch for Notch target genes.

Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Jones Katherine A
Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037-1099, USA. [email protected]
References (10)
10 references, click to expand
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Article Info
Journal
Molecular cell
Abbr.
Mol Cell
ISSN
1097-4164
DOI
10.1016/j.molcel.2011.05.017
Email
[email protected]
Published
2011-06-10
Pages
559-60
Language
English
Region
United States
NLM ID
9802571
PMCID
PMC3491984
Grants
NCI NIH HHS · R01 CA125535 · United States
NIGMS NIH HHS · R01 GM067127 · United States
Corrections
CommentOn
PMID: 21596603
External Links
PubMed source DOI: 10.1016/j.molcel.2011.05.017 PMC Full Text View journal details
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