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PMID: 2166951 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 87 ·No. 16 ·1990-08-00 ·Pages 6233-7

Giguère V, Lyn S, Yip P, Siu CH, Amin S

Abstract

The vitamin A derivative retinoic acid is known to be a potent agent for control of differentiation and proliferation of epithelial cells and to exert profound effects on pattern formation during embryogenesis. Its action at the molecular level appears to be mediated by two distinct classes of proteins: a family of nuclear receptors that regulates gene transcription in a ligand-dependent fashion and a small cellular retinoic acid-binding protein (CRABP) for which a precise function remains to be elucidated. In this report, we describe the identification (by molecular cloning of its cDNA) of an isoform of CRABP, referred to as CRABP-II, expressed at high levels during mouse embryogenesis and in adult skin. We also show that CRABP-II mRNA levels are induced by at least 50-fold upon treatment of F9 teratocarcinoma cells with retinoic acid. The up-regulation of the gene encoding CRABP-II by its ligand suggests that CRABP-II might be involved in a feedback regulatory role in the mechanism of action of retinoic acid on cellular differentiation.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Carrier Proteins/genetics,metabolism Cell Line Cloning, Molecular DNA/genetics Mice Molecular Sequence Data Receptors, Retinoic Acid Recombinant Proteins/metabolism Restriction Mapping Sequence Homology, Nucleic Acid Transfection Tretinoin/metabolism
Chemicals
Carrier Proteins Receptors, Retinoic Acid Recombinant Proteins Tretinoin DNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Giguère V
Division of Endocrinology, Hospital for Sick Children, Toronto, ON, Canada.
Lyn S
Yip P
Siu C H
Amin S
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31 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.87.16.6233
Published
1990-08-00
Pages
6233-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC54507
Subset
IM
Databases
GENBANK
M35523
External Links
PubMed source DOI: 10.1073/pnas.87.16.6233 PMC Full Text View journal details
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