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PMID: 21678027 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation.

Medical oncology (Northwood, London, England) ·Vol. 29 ·No. 3 ·2012-09-00 ·Pages 1810-6

Lai MC, Yang Z, Zhou L, Zhu QQ, Xie HY, Zhang F, Wu LM, Chen LM, Zheng SS

Abstract

Metastasis-associated lung adenocarcinoma transcript 1(MALAT1), a long non-coding RNA (lncRNA), is up-regulated in many solid tumors and associated with cancer metastasis and recurrence. However, its role in hepatocellular carcinoma (HCC) remains poorly understood. In the present study, we evaluated the expression of MALAT1 by quantitative real-time PCR in 9 liver cancer cell lines and 112 HCC cases including 60 cases who received liver transplantation (LT) with complete follow-up data. Moreover, small interfering RNA (siRNA) was used to inhibit MALAT1 expression to investigate its biological role in tumor progression. We found that MALAT1 was up-regulated in both cell lines and clinical tissue samples. Patients with high expression level of MALAT1 had a significantly increased risk of tumor recurrence after LT, particularly in patients who exceeded the Milan criteria. On multivariate analysis, MALAT1 was an independent prognostic factor for predicting HCC recurrence (hazard ratio, 3.280, P = 0.003).In addition, inhibition of MALAT1 in HepG2 cells could effectively reduce cell viability, motility, invasiveness, and increase the sensitivity to apoptosis. Our data suggest that lncRNA MALAT1 play an important role in tumor progression and could be a novel biomarker for predicting tumor recurrence after LT and serve as a promising therapeutic target.

MeSH Terms
Adult Carcinoma, Hepatocellular/genetics,pathology Female Humans Liver Neoplasms/genetics,pathology Liver Transplantation/adverse effects Male Middle Aged Neoplasm Grading Neoplasm Recurrence, Local/genetics,pathology Prognosis RNA, Long Noncoding/genetics RNA, Small Interfering Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Transfection
Chemicals
MALAT1 long non-coding RNA, human RNA, Long Noncoding RNA, Small Interfering
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Lai Ming-chun
Department of Hepatobiliary and Pancreatic Surgery, Key Lab of Combined Multi-organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, People's Republic of China.
Yang Zhe
Zhou Lin
Zhu Qian-qian
Xie Hai-yang
Zhang Feng
Wu Li-ming
Chen Lei-ming
Zheng Shu-sen
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Article Info
Journal
Medical oncology (Northwood, London, England)
Abbr.
Med Oncol
ISSN
1559-131X
Published
2012-09-00
Epub
2011-00-16
Pages
1810-6
Language
English
Region
United States
NLM ID
9435512
Subset
IM
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