Abstract
Metastasis-associated lung adenocarcinoma transcript 1(MALAT1), a long non-coding RNA (lncRNA), is up-regulated in many solid tumors and associated with cancer metastasis and recurrence. However, its role in hepatocellular carcinoma (HCC) remains poorly understood. In the present study, we evaluated the expression of MALAT1 by quantitative real-time PCR in 9 liver cancer cell lines and 112 HCC cases including 60 cases who received liver transplantation (LT) with complete follow-up data. Moreover, small interfering RNA (siRNA) was used to inhibit MALAT1 expression to investigate its biological role in tumor progression. We found that MALAT1 was up-regulated in both cell lines and clinical tissue samples. Patients with high expression level of MALAT1 had a significantly increased risk of tumor recurrence after LT, particularly in patients who exceeded the Milan criteria. On multivariate analysis, MALAT1 was an independent prognostic factor for predicting HCC recurrence (hazard ratio, 3.280, P = 0.003).In addition, inhibition of MALAT1 in HepG2 cells could effectively reduce cell viability, motility, invasiveness, and increase the sensitivity to apoptosis. Our data suggest that lncRNA MALAT1 play an important role in tumor progression and could be a novel biomarker for predicting tumor recurrence after LT and serve as a promising therapeutic target.
MeSH Terms
Adult
Carcinoma, Hepatocellular/genetics,pathology
Female
Humans
Liver Neoplasms/genetics,pathology
Liver Transplantation/adverse effects
Male
Middle Aged
Neoplasm Grading
Neoplasm Recurrence, Local/genetics,pathology
Prognosis
RNA, Long Noncoding/genetics
RNA, Small Interfering
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Transfection
Chemicals
MALAT1 long non-coding RNA, human
RNA, Long Noncoding
RNA, Small Interfering
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Lai Ming-chun
Department of Hepatobiliary and Pancreatic Surgery, Key Lab of Combined Multi-organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, People's Republic of China.
Yang Zhe
Zhou Lin
Zhu Qian-qian
Xie Hai-yang
Zhang Feng
Wu Li-ming
Chen Lei-ming
Zheng Shu-sen
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