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PMID: 21699508 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins.

British journal of pharmacology ·Vol. 165 ·No. 6 ·2012-03-00 ·Pages 1717-1736

Magalhaes AC, Dunn H, Ferguson SS

Abstract

GPCRs represent the largest family of integral membrane proteins and were first identified as receptor proteins that couple via heterotrimeric G-proteins to regulate a vast variety of effector proteins to modulate cellular function. It is now recognized that GPCRs interact with a myriad of proteins that not only function to attenuate their signalling but also function to couple these receptors to heterotrimeric G-protein-independent signalling pathways. In addition, intracellular and transmembrane proteins associate with GPCRs and regulate their processing in the endoplasmic reticulum, trafficking to the cell surface, compartmentalization to plasma membrane microdomains, endocytosis and trafficking between intracellular membrane compartments. The present review will overview the functional consequence of β-arrestin, receptor activity-modifying proteins (RAMPS), regulators of G-protein signalling (RGS), GPCR-associated sorting proteins (GASPs), Homer, small GTPases, PSD95/Disc Large/Zona Occludens (PDZ), spinophilin, protein phosphatases, calmodulin, optineurin and Src homology 3 (SH3) containing protein interactions with GPCRs.

MeSH Terms
Animals Arrestins/metabolism G-Protein-Coupled Receptor Kinases/metabolism GTP-Binding Proteins/metabolism Humans Protein Transport Receptor Activity-Modifying Proteins/metabolism Receptors, G-Protein-Coupled/metabolism Vesicular Transport Proteins/metabolism
Chemicals
Arrestins Receptor Activity-Modifying Proteins Receptors, G-Protein-Coupled Vesicular Transport Proteins G-Protein-Coupled Receptor Kinases GTP-Binding Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Magalhaes Ana C
J. Allyn Taylor Centre for Cell Biology, Molecular Brain Research Group, Robarts Research Institute, London, ON, CanadaThe Department of Physiology & Pharmacology, the University of Western Ontario, London, ON, Canada.
Dunn Henry
J. Allyn Taylor Centre for Cell Biology, Molecular Brain Research Group, Robarts Research Institute, London, ON, CanadaThe Department of Physiology & Pharmacology, the University of Western Ontario, London, ON, Canada.
Ferguson Stephen Sg
J. Allyn Taylor Centre for Cell Biology, Molecular Brain Research Group, Robarts Research Institute, London, ON, CanadaThe Department of Physiology & Pharmacology, the University of Western Ontario, London, ON, Canada.
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
1476-5381
DOI
10.1111/j.1476-5381.2011.01552.x
Published
2012-03-00
Pages
1717-1736
Language
English
Region
England
NLM ID
7502536
PMCID
PMC3372825
Subset
IM
Grants
Canadian Institutes of Health Research · MA-15506 · Canada
Canadian Institutes of Health Research · MOP 62738 · Canada
External Links
PubMed source DOI: 10.1111/j.1476-5381.2011.01552.x PMC Full Text View journal details
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