L-aspartate: evidence for a role in cone photoreceptor synaptic transmission in the carp retina.
A number of putative neurotransmitter substances and their antagonists were applied to the carp retina while intracellular recordings from L-type cone horizontal cells were made. Of all the substances tested, L-aspartate was found to be the most potent agent in depolarizing these horizontal cells in dark-adapted, partially light-adapted, and Co2+-treated retinas. Furthermore, DL-alpha-aminoadipate, an L-aspartate antagonist, blocked the effects of both the endogenous photoreceptor transmitter and exogenously applied L-aspartate on the horizontal cells. The results suggest that L-aspartate and the natural transmitter interact with the same population of postsynaptic receptors in the horizontal cell membrane.
21 references, click to expand
-
The actions of certain amino acids as neuronal excitants [proceedings].J Physiol. 1977 Oct;272(1):52P-53P PMID: 592150
-
Muscarinic antagonists block cone to horizontal cell transmission in turtle retina.Nature. 1977 Jul 21;268(5617):257-9 PMID: 196207
-
D-alpha-Aminoadipate as a selective antagonist of amino acid-induced and synaptic excitation of mammalian spinal neurones.Nature. 1977 Dec 22-29;270(5639):743-5 PMID: 22820
-
Amino acid transmitter substances in the vertebrate retina.Gen Pharmacol. 1976 Oct;7(5):321-32 PMID: 789174
-
Effects of chemicals on receptors and horizontal cells in the retina.J Physiol. 1972 Dec;227(3):899-913 PMID: 4405555
-
[Reaction of cells--sources of S-potentials of turtle retina--to current conducted through the eye goblet].Biofizika. 1965;10(4):673-80 PMID: 5868376
-
Dark current and photocurrent in retinal rods.Biophys J. 1970 May;10(5):380-412 PMID: 5439318
-
Autoradiography of some suspected neurotransmitter substances: GABA glycine, glutamic acid, histamine, dopamine, and L-dopa.Brain Res. 1971 Oct 8;33(1):157-72 PMID: 4399083
-
Excitation of mammalian central neurones by acidic amino acids.Brain Res. 1972 Jun 22;41(2):283-301 PMID: 4402606
-
Interactions of rod and cone signals in the mudpuppy retina.J Physiol. 1975 Nov;252(3):735-69 PMID: 1206574
-
Effect of magnesium on horizontal cell activity in the skate retina.Nature. 1973 Mar 9;242(5393):101-3 PMID: 4348460
-
The antagonistic action of glutamic acid diethylester towards amino acid-induced and synaptic excitations of central neurones.Brain Res. 1972 Oct 27;45(2):393-400 PMID: 4343918
-
Synaptic transmission between photoreceptors and horizontal cells in the turtle retina.Science. 1974 Feb 1;183(4123):417-9 PMID: 4358073
-
Synaptic activity of frog retinal photoreceptors. A peroxidase uptake study.J Cell Biol. 1976 Jul;70(1):178-92 PMID: 1084350
-
Effects of aspartate and glutamate on the bipolar cells in the carp retina.Vision Res. 1975 Mar;15(3):456-8 PMID: 166508
-
Photoreceptor-bipolar cell transmission in the perfused retina eyecup of the mudpuppy.Science. 1976 Mar 5;191(4230):963-4 PMID: 175443
-
Effects of some amino acids on the horizontal cell membrane potential in the isolated carp retina.Vision Res. 1973 May;13(5):977-81 PMID: 4706721
-
Adaptation in skate photoreceptors.J Gen Physiol. 1972 Dec;60(6):698-719 PMID: 4645677
-
Inactivation of horizontal cells in turtle retina by glutamate and aspartate.Science. 1972 Nov 17;178(4062):767-8 PMID: 5082843
-
Peroxidase uptake by photoreceptor terminals of the skate retina.J Cell Biol. 1976 Jul;70(1):86-96 PMID: 932103
-
S-potentials in the skate retina. Intracellular recordings during light and dark adaptation.J Gen Physiol. 1971 Aug;58(2):163-89 PMID: 5559621
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
