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PMID: 21717116 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study.

Diabetologia ·Vol. 54 ·No. 9 ·2011-09-00 ·Pages 2272-82

InterAct Consortium, Langenberg C, Sharp S, Forouhi NG, Franks PW, Schulze MB, Kerrison N, Ekelund U, Barroso I, Panico S, Tormo MJ, Spranger J, Griffin S, van der Schouw YT, Amiano P, Ardanaz E, Arriola L, Balkau B, Barricarte A, Beulens JW, Boeing H, Bueno-de-Mesquita HB, Buijsse B, Chirlaque Lopez MD, Clavel-Chapelon F, Crowe FL, de Lauzon-Guillan B, Deloukas P, Dorronsoro M, Drogan D, Froguel P, Gonzalez C, Grioni S, Groop L, Groves C, Hainaut P, Halkjaer J, Hallmans G, Hansen T, Huerta Castaño JM, Kaaks R, Key TJ, Khaw KT, Koulman A, Mattiello A, Navarro C, Nilsson P, Norat T, Overvad K, Palla L, Palli D, Pedersen O, Peeters PH, Quirós JR, Ramachandran A, Rodriguez-Suarez L, Rolandsson O, Romaguera D, Romieu I, Sacerdote C, Sánchez MJ, Sandbaek A, Slimani N, Sluijs I, Spijkerman AM, Teucher B, Tjonneland A, Tumino R, van der A DL, Verschuren WM, Tuomilehto J, Feskens E, McCarthy M, Riboli E, Wareham NJ

Abstract

Studying gene-lifestyle interaction may help to identify lifestyle factors that modify genetic susceptibility and uncover genetic loci exerting important subgroup effects. Adequately powered studies with prospective, unbiased, standardised assessment of key behavioural factors for gene-lifestyle studies are lacking. This case-cohort study aims to investigate how genetic and potentially modifiable lifestyle and behavioural factors, particularly diet and physical activity, interact in their influence on the risk of developing type 2 diabetes. Incident cases of type 2 diabetes occurring in European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts between 1991 and 2007 from eight of the ten EPIC countries were ascertained and verified. Prentice-weighted Cox regression and random-effects meta-analyses were used to investigate differences in diabetes incidence by age and sex. A total of 12,403 verified incident cases of type 2 diabetes occurred during 3.99 million person-years of follow-up of 340,234 EPIC participants eligible for InterAct. We defined a centre-stratified subcohort of 16,154 individuals for comparative analyses. Individuals with incident diabetes who were randomly selected into the subcohort (n = 778) were included as cases in the analyses. All prevalent diabetes cases were excluded from the study. InterAct cases were followed-up for an average of 6.9 years; 49.7% were men. Mean baseline age and age at diagnosis were 55.6 and 62.5 years, mean BMI and waist circumference values were 29.4 kg/m(2) and 102.7 cm in men, and 30.1 kg/m(2) and 92.8 cm in women, respectively. Risk of type 2 diabetes increased linearly with age, with an overall HR of 1.56 (95% CI 1.48-1.64) for a 10 year age difference, adjusted for sex. A male excess in the risk of incident diabetes was consistently observed across all countries, with a pooled HR of 1.51 (95% CI 1.39-1.64), adjusted for age. InterAct is a large, well-powered, prospective study that will inform our understanding of the interplay between genes and lifestyle factors on the risk of type 2 diabetes development.

MeSH Terms

Cohort Studies Diabetes Mellitus, Type 2/epidemiology,genetics,physiopathology Diet Europe/epidemiology Female Follow-Up Studies Genetic Predisposition to Disease/genetics Humans Incidence International Cooperation Life Style Male Middle Aged Motor Activity/physiology Prospective Studies Retrospective Studies Risk Factors

Authors & Affiliations

75 authors, click to expand affiliations / ORCID

InterAct Consortium

Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Box 285, Cambridge CB2 0QQ, UK e-mail: [email protected]

Langenberg C

Sharp S

Forouhi N G

Franks P W

Schulze M B

Kerrison N

Ekelund U

Barroso I

Panico S

Tormo M J

Spranger J

Griffin S

van der Schouw Y T

Amiano P

Ardanaz E

Arriola L

Balkau B

Barricarte A

Beulens J W J

Boeing H

Bueno-de-Mesquita H B

Buijsse B

Chirlaque Lopez M D

Clavel-Chapelon F

Crowe F L

de Lauzon-Guillan B

Deloukas P

Dorronsoro M

Drogan D

Froguel P

Gonzalez C

Grioni S

Groop L

Groves C

Hainaut P

Halkjaer J

Hallmans G

Hansen T

Huerta Castaño J M

Kaaks R

Key T J

Khaw K T

Koulman A

Mattiello A

Navarro C

Nilsson P

Norat T

Overvad K

Palla L

Palli D

Pedersen O

Peeters P H

Quirós J R

Ramachandran A

Rodriguez-Suarez L

Rolandsson O

Romaguera D

Romieu I

Sacerdote C

Sánchez M J

Sandbaek A

Slimani N

Sluijs I

Spijkerman A M W

Teucher B

Tjonneland A

Tumino R

van der A D L

Verschuren W M M

Tuomilehto J

Feskens E

McCarthy M

Riboli E

Wareham N J

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Article Info

Journal

Diabetologia

Abbr.

Diabetologia

ISSN

1432-0428

DOI

10.1007/s00125-011-2182-9

[email protected]

Published

2011-09-00

Epub

2011-00-30

Pages

2272-82

Language

English

Region

Germany

NLM ID

0006777

PMCID

PMC4222062

Subset

Grants

CIHR · G0601261 · Canada

Medical Research Council · G1000143 · United Kingdom

Medical Research Council · MC_U106179473 · United Kingdom

Medical Research Council · MC_U106179471 · United Kingdom

Medical Research Council · G0401527 · United Kingdom

Wellcome Trust · 083270/083270/z · United Kingdom

Medical Research Council · MC_UP_A090_1006 · United Kingdom

Medical Research Council · G0601261 · United Kingdom

Cancer Research UK · United Kingdom

Medical Research Council · MC_EX_G0800783 · United Kingdom

Medical Research Council · MC_UP_A100_1003 · United Kingdom

Wellcome Trust · 090532 · United Kingdom

Medical Research Council · MC_U106179474 · United Kingdom

External Links

PubMed source DOI: 10.1007/s00125-011-2182-9 PMC Full Text View journal details

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Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study.

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