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PMID: 21734722 Published · epublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Review

Cancer biology and NuRD: a multifaceted chromatin remodelling complex.

Nature reviews. Cancer ·Vol. 11 ·No. 8 ·2011-07-07 ·Pages 588-96

Lai AY, Wade PA

Abstract

The nucleosome remodelling and histone deacetylase (NuRD; also known as Mi-2) complex regulates gene expression at the level of chromatin. The NuRD complex has been identified - using both genetic and molecular analyses - as a key determinant of differentiation in mouse embryonic stem cells and during development in various model systems. Similar to other chromatin remodellers, such as SWI/SNF and Polycomb complexes, NuRD has also been implicated in the regulation of transcriptional events that are integral to oncogenesis and cancer progression. Emerging molecular details regarding the recruitment of NuRD to specific loci during development, and the modulation of these events in cancer, are used to illustrate how the inappropriate localization of the complex could contribute to tumour biology.

MeSH Terms
Animals Chromatin Chromatin Assembly and Disassembly DNA Methylation DNA-Binding Proteins/genetics Gene Expression Regulation Gene Silencing Genomic Instability Humans Mi-2 Nucleosome Remodeling and Deacetylase Complex/physiology Neoplasms/drug therapy,genetics,physiopathology Promoter Regions, Genetic
Chemicals
Chromatin DNA-Binding Proteins MBD2 protein Mi-2 Nucleosome Remodeling and Deacetylase Complex
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lai Anne Y
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina NC 27709, USA. [email protected]
Wade Paul A
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Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc3091
Email
[email protected]
Published
2011-07-07
Epub
2011-00-07
Pages
588-96
Language
English
Region
England
NLM ID
101124168
PMCID
PMC4157524
Subset
IM
Grants
Intramural NIH HHS · Z01 ES101965 · United States
Intramural NIH HHS · ZIA ES101965-07 · United States
NIEHS NIH HHS · Z01ES101965 · United States
External Links
PubMed source DOI: 10.1038/nrc3091 PMC Full Text View journal details
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