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PMID: 217506 Published · ppublish English Journal Article Review

Mechanisms of recovery from Herpesvirus infections -a review.

Canadian journal of comparative medicine : Revue canadienne de medecine comparee ·Vol. 42 ·No. 4 ·1978-10-00 ·Pages 414-27

Rouse BT, Babiuk LA

Abstract

A variety of specific immunological mechanisms have been shown to be effective at neutralizing herpesviruses or destroying herpesvirus infected cells. These include both humoral and cell mediated immune responses or combinations thereof. Thus, it is genarlly accepted that humoral immunity is probably responsible for preventing reinfection whereas cellular immunity, mediated by T lymphocytes or by the interaction of antibody and Fc receptor bearing cells, is more important in recovery from infections. In addition to these specific responses to herpesvirus infection, a number of nonspecific cellular and humoral components have been shown to inhibit the progression of virus replication and therefore, have been implicated in assisting the host in the recovery process. The various interactions and counteractions between the various nonspecific and specific components of the immune response are discussed with respect to their role in recovery from both primary and recurrent disease as well as how they may eventually be manipulated so as to control herpesvirus recrudescent disease.

MeSH Terms
Animals Antibodies, Viral Antibody Formation Antibody-Dependent Cell Cytotoxicity Cattle Complement Activation Complement Pathway, Classical Endocytosis Herpesviridae/immunology Herpesviridae Infections/immunology,veterinary Herpesvirus 1, Bovine/immunology Immunity Immunity, Cellular Interferons/biosynthesis Macrophages/physiology Neutrophils/physiology T-Lymphocytes/immunology Virus Replication
Chemicals
Antibodies, Viral Interferons
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rouse B T
Babiuk L A
References (70)
70 references, click to expand
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Article Info
Journal
Canadian journal of comparative medicine : Revue canadienne de medecine comparee
Abbr.
Can J Comp Med
ISSN
0008-4050
Published
1978-10-00
Pages
414-27
Language
English
Region
Canada
NLM ID
0151747
PMCID
PMC1277666
Subset
IM
External Links
PubMed source PMC Full Text
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