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PMID: 21802130 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?

Cell ·Vol. 146 ·No. 3 ·2011-08-05 ·Pages 353-8

Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP

Abstract

Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.

MeSH Terms
Animals Gene Expression Profiling Gene Expression Regulation Humans MicroRNAs/genetics Neoplasms/genetics,metabolism Pseudogenes RNA/genetics,metabolism RNA, Messenger/genetics RNA, Untranslated/genetics
Chemicals
MicroRNAs RNA, Messenger RNA, Untranslated RNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Salmena Leonardo
Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Poliseno Laura
Tay Yvonne
Kats Lev
Pandolfi Pier Paolo
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Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2011.07.014
Published
2011-08-05
Epub
2011-00-28
Pages
353-8
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC3235919
Subset
IM
Grants
NCI NIH HHS · R01 CA082328 · United States
NCI NIH HHS · R01 CA082328-14 · United States
NCI NIH HHS · R01 CA-82328-09 · United States
CIHR · Canada
External Links
PubMed source DOI: 10.1016/j.cell.2011.07.014 PMC Full Text View journal details
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