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PMID: 21805404 Published · ppublish English Journal Article Review

The discovery of LOX-1, its ligands and clinical significance.

Cardiovascular drugs and therapy ·Vol. 25 ·No. 5 ·2011-10-00 ·Pages 379-91

Yoshimoto R, Fujita Y, Kakino A, Iwamoto S, Takaya T, Sawamura T

Abstract

LOX-1 is an endothelial receptor for oxidized low-density lipoprotein (oxLDL), a key molecule in the pathogenesis of atherosclerosis.The basal expression of LOX-1 is low but highly induced under the influence of proinflammatory and prooxidative stimuli in vascular endothelial cells, smooth muscle cells, macrophages, platelets and cardiomyocytes. Multiple lines of in vitro and in vivo studies have provided compelling evidence that LOX-1 promotes endothelial dysfunction and atherogenesis induced by oxLDL. The roles of LOX-1 in the development of atherosclerosis, however, are not simple as it had been considered. Evidence has been accumulating that LOX-1 recognizes not only oxLDL but other atherogenic lipoproteins, platelets, leukocytes and CRP. As results, LOX-1 not only mediates endothelial dysfunction but contributes to atherosclerotic plaque formation, thrombogenesis, leukocyte infiltration and myocardial infarction, which determine mortality and morbidity from atherosclerosis. Moreover, our recent epidemiological study has highlighted the involvement of LOX-1 in human cardiovascular diseases. Further understandings of LOX-1 and its ligands as well as its versatile functions will direct us to ways to find novel diagnostic and therapeutic approaches to cardiovascular disease.

MeSH Terms
Animals Cardiovascular Diseases/metabolism,pathology Endothelium, Vascular/metabolism Humans Ligands Lipoproteins, LDL/metabolism Scavenger Receptors, Class E/metabolism
Chemicals
Ligands Lipoproteins, LDL Scavenger Receptors, Class E oxidized low density lipoprotein
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Yoshimoto Ryo
Department of Vascular Physiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Fujita Yoshiko
Kakino Akemi
Iwamoto Shin
Takaya Tomohide
Sawamura Tatsuya
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Article Info
Journal
Cardiovascular drugs and therapy
Abbr.
Cardiovasc Drugs Ther
ISSN
1573-7241
DOI
10.1007/s10557-011-6324-6
Published
2011-10-00
Pages
379-91
Language
English
Region
United States
NLM ID
8712220
PMCID
PMC3204104
Subset
IM
External Links
PubMed source DOI: 10.1007/s10557-011-6324-6 PMC Full Text View journal details
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