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PMID: 21910625 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Fetal programming and metabolic syndrome.

Annual review of physiology ·Vol. 74 ·2012-00-00 ·Pages 107-30

Rinaudo P, Wang E

Abstract

Metabolic syndrome is reaching epidemic proportions, particularly in developing countries. In this review, we explore the concept-based on the developmental-origin-of-health-and-disease hypothesis-that reprogramming during critical times of fetal life can lead to metabolic syndrome in adulthood. Specifically, we summarize the epidemiological evidence linking prenatal stress, manifested by low birth weight, to metabolic syndrome and its individual components. We also review animal studies that suggest potential mechanisms for the long-term effects of fetal reprogramming, including the cellular response to stress and both organ- and hormone-specific alterations induced by stress. Although metabolic syndrome in adulthood is undoubtedly caused by multiple factors, including modifiable behavior, fetal life may provide a critical window in which individuals are predisposed to metabolic syndrome later in life.

MeSH Terms
Adult Animals Cell Biology Female Fetal Development/physiology Humans Hypothalamo-Hypophyseal System/physiology Infant, Newborn Metabolic Syndrome/physiopathology Models, Biological Nutritional Physiological Phenomena Organ Specificity Pregnancy Prenatal Exposure Delayed Effects Species Specificity Stress, Physiological
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rinaudo Paolo
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94115, USA. [email protected]
Wang Erica
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Article Info
Journal
Annual review of physiology
Abbr.
Annu Rev Physiol
ISSN
1545-1585
DOI
10.1146/annurev-physiol-020911-153245
Email
[email protected]
Published
2012-00-00
Epub
2011-00-09
Pages
107-30
Language
English
Region
United States
NLM ID
0370600
PMCID
PMC4132057
Subset
IM
Grants
NICHD NIH HHS · R01 HD062803 · United States
NICHD NIH HHS · R01 HD062803-02 · United States
External Links
PubMed source DOI: 10.1146/annurev-physiol-020911-153245 PMC Full Text View journal details
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