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PMID: 21914164 Published · epublish English Journal Article

Interaction of tumor cells with the microenvironment.

Cell communication and signaling : CCS ·Vol. 9 ·2011-09-13 ·Pages 18

Ungefroren H, Sebens S, Seidl D, Lehnert H, Hass R

Abstract

Recent advances in tumor biology have revealed that a detailed analysis of the complex interactions of tumor cells with their adjacent microenvironment (tumor stroma) is mandatory in order to understand the various mechanisms involved in tumor growth and the development of metastasis. The mutual interactions between tumor cells and cellular and non-cellular components (extracellular matrix = ECM) of the tumor microenvironment will eventually lead to a loss of tissue homeostasis and promote tumor development and progression. Thus, interactions of genetically altered tumor cells and the ECM on the one hand and reactive non-neoplastic cells on the other hand essentially control most aspects of tumorigenesis such as epithelial-mesenchymal-transition (EMT), migration, invasion (i.e. migration through connective tissue), metastasis formation, neovascularisation, apoptosis and chemotherapeutic drug resistance. In this mini-review we will focus on these issues that were recently raised by two review articles in CCS.

Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ungefroren Hendrik
First Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. [email protected].
Sebens Susanne
Seidl Daniel
Lehnert Hendrik
Hass Ralf
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Article Info
Journal
Cell communication and signaling : CCS
Abbr.
Cell Commun Signal
ISSN
1478-811X
DOI
10.1186/1478-811X-9-18
Email
[email protected]
Published
2011-09-13
Epub
2011-00-13
Pages
18
Language
English
Region
England
NLM ID
101170464
PMCID
PMC3180438
External Links
PubMed source DOI: 10.1186/1478-811X-9-18 PMC Full Text View journal details
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