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PMID: 219262 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Anatomy of herpes simplex virus DNA. XI. Apparent clustering of functions effecting rapid inhibition of host DNA and protein synthesis.

Journal of virology ·Vol. 29 ·No. 2 ·1979-02-00 ·Pages 825-7

Fenwick M, Morse LS, Roizman B

Abstract

Herpes simplex virus type 2 (HSV-2) strains inhibit the synthesis of both DNA and protein of the host cell more rapidly than HSV-1 strains. Several intertypic HSV-1 X HSV-2 recombinants and parental strains were examined for their ability to inhibit rapidly the synthesis of host protein and DNA. The two functions cosegregated in all of eight recombinants tested and are therefore controlled by the same gene or by different genes in the same region of the viral DNA.

MeSH Terms
Animals Cell Line DNA/biosynthesis DNA, Viral/genetics Dactinomycin/pharmacology Genes, Viral Haplorhini Kidney Protein Biosynthesis Recombination, Genetic Simplexvirus/genetics,radiation effects Ultraviolet Rays
Chemicals
DNA, Viral Dactinomycin DNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Fenwick M
Morse L S
Roizman B
References (9)
9 references, click to expand
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    Virology. 1977 Apr;77(2):733-49 PMID: 193259
  6. Characterization of herpes simplex virus strains differing in their effects on social behaviour of infected cells.
    J Gen Virol. 1968 May;2(3):357-64 PMID: 4300104
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    Science. 1966 Jul 1;153(3731):76-8 PMID: 4287165
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    Nature. 1965 Jun 26;206(991):1374-5 PMID: 4284477
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.29.2.825-827.1979
Published
1979-02-00
Pages
825-7
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC353224
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.29.2.825-827.1979 PMC Full Text View journal details
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