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PMID: 21949384 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Complex genetic architecture of Drosophila aggressive behavior.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 108 ·No. 41 ·2011-10-11 ·Pages 17070-5

Zwarts L, Magwire MM, Carbone MA, Versteven M, Herteleer L, Anholt RR, Callaerts P, Mackay TF

Abstract

Epistasis and pleiotropy feature prominently in the genetic architecture of quantitative traits but are difficult to assess in outbred populations. We performed a diallel cross among coisogenic Drosophila P-element mutations associated with hyperaggressive behavior and showed extensive epistatic and pleiotropic effects on aggression, brain morphology, and genome-wide transcript abundance in head tissues. Epistatic interactions were often of greater magnitude than homozygous effects, and the topology of epistatic networks varied among these phenotypes. The transcriptional signatures of homozygous and double heterozygous genotypes derived from the six mutations imply a large mutational target for aggressive behavior and point to evolutionarily conserved genetic mechanisms and neural signaling pathways affecting this universal fitness trait.

MeSH Terms
Aggression/physiology Animals Behavior, Animal/physiology Brain/anatomy & histology Crosses, Genetic Drosophila melanogaster/anatomy & histology,genetics,physiology Epistasis, Genetic Evolution, Molecular Female Gene Expression Gene Regulatory Networks Genes, Insect Male Mutation Phenotype
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Zwarts Liesbeth
Laboratory of Developmental Genetics, Center for Human Genetics, Catholic University Leuven and Flemish Institute for Biotechnology, B-3000 Leuven, Belgium.
Magwire Michael M
Carbone Mary Anna
Versteven Marijke
Herteleer Liesbet
Anholt Robert R H
Callaerts Patrick
Mackay Trudy F C
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
1091-6490
DOI
10.1073/pnas.1113877108
Published
2011-10-11
Epub
2011-00-26
Pages
17070-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC3193212
Subset
IM
Grants
NIGMS NIH HHS · R01 GM076083 · United States
External Links
PubMed source DOI: 10.1073/pnas.1113877108 PMC Full Text View journal details
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