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PMID: 2197215 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

T cells do not mediate the initial suppression of a Salmonella infection in the RES.

Immunology ·Vol. 70 ·No. 2 ·1990-06-00 ·Pages 247-50

Hormaeche CE, Mastroeni P, Arena A, Uddin J, Joysey HS

Abstract

The course of a sublethal salmonella infection was followed in mice rendered susceptible by irradiation, reconstituted with T-cell-depleted bone marrow from normal donors and given a synergistic pool of CD4 and CD8 monoclonal antibodies. The results indicate that the host response causing the early plateau and suppression of bacterial growth at the end of the first week of the infection, which is essential for survival, does not require T cells.

MeSH Terms
Animals Bone Marrow Transplantation/immunology Immunity/radiation effects Immunization, Passive Mice Mice, Inbred Strains Mononuclear Phagocyte System/immunology Salmonella Infections, Animal/immunology,microbiology Salmonella typhimurium/growth & development T-Lymphocytes/immunology Whole-Body Irradiation
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hormaeche C E
Department of Pathology, University of Cambridge, U.K.
Mastroeni P
Arena A
Uddin J
Joysey H S
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20 references, click to expand
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1990-06-00
Pages
247-50
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1384201
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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