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PMID: 2200166 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The evolution of alpha/beta barrel enzymes.

Trends in biochemical sciences ·Vol. 15 ·No. 6 ·1990-06-00 ·Pages 228-34

Farber GK, Petsko GA

Abstract

Of the enzymes whose structure is known, roughly one out of ten has an eight-stranded alpha/beta barrel domain. Structural and chemical evidence suggests that all of these domains may have diverged from a common ancestor.

MeSH Terms
Amino Acid Sequence Biological Evolution Enzymes/genetics Isomerases/genetics Lyases/genetics Molecular Sequence Data Oxidoreductases/genetics Protein Conformation Structure-Activity Relationship Triose-Phosphate Isomerase/genetics
Chemicals
Enzymes Oxidoreductases Lyases Isomerases Triose-Phosphate Isomerase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Farber G K
Department of Chemistry, Pennsylvania State University, University Park 16802.
Petsko G A
Article Info
Journal
Trends in biochemical sciences
Abbr.
Trends Biochem Sci
ISSN
0968-0004
DOI
10.1016/0968-0004(90)90035-a
Published
1990-06-00
Pages
228-34
Language
English
Region
England
NLM ID
7610674
Subset
IM
Grants
NIGMS NIH HHS · GM26788 · United States
External Links
PubMed source DOI: 10.1016/0968-0004(90)90035-a View journal details
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