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PMID: 22002716 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Cyclooxygenases and lipoxygenases in cancer.

Cancer metastasis reviews ·Vol. 30 ·No. 3-4 ·2011-12-00 ·Pages 277-94

Schneider C, Pozzi A

Abstract

Cancer initiation and progression are multistep events that require cell proliferation, migration, extravasation to the blood or lymphatic vessels, arrest to the metastatic site, and ultimately secondary growth. Tumor cell functions at both primary or secondary sites are controlled by many different factors, including growth factors and their receptors, chemokines, nuclear receptors, cell-cell interactions, cell-matrix interactions, as well as oxygenated metabolites of arachidonic acid. The observation that cyclooxygenases and lipoxygenases and their arachidonic acid-derived eicosanoid products (prostanoids and HETEs) are expressed and produced by tumor cells, together with the finding that these enzymes can regulate cell growth, survival, migration, and invasion, has prompted investigators to analyze the roles of these enzymes in cancer progression. In this review, we focus on the contribution of cyclooxygenase- and lipoxygenase-derived eicosanoids to tumor cell function in vitro and in vivo and discuss hope and tribulations of targeting these enzymes for cancer prevention and treatment.

MeSH Terms
Animals Antineoplastic Agents/pharmacology Arachidonate Lipoxygenases/antagonists & inhibitors,metabolism Cell Transformation, Neoplastic/drug effects Cyclooxygenase Inhibitors/pharmacology Eicosanoids/biosynthesis,metabolism Humans Linoleic Acids/metabolism Neoplasms/enzymology,prevention & control Prostaglandin-Endoperoxide Synthases/metabolism
Chemicals
Antineoplastic Agents Cyclooxygenase Inhibitors Eicosanoids Linoleic Acids 13-hydroxy-9,11-octadecadienoic acid Arachidonate Lipoxygenases Prostaglandin-Endoperoxide Synthases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schneider Claus
Department of Pharmacology, Vanderbilt University Medical School, Nashville, TN 37232, USA.
Pozzi Ambra
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Article Info
Journal
Cancer metastasis reviews
Abbr.
Cancer Metastasis Rev
ISSN
1573-7233
DOI
10.1007/s10555-011-9310-3
Published
2011-12-00
Pages
277-94
Language
English
Region
Netherlands
NLM ID
8605731
PMCID
PMC3798028
Subset
IM
Grants
NIDDK NIH HHS · P30 DK079341 · United States
NIDDK NIH HHS · P01 DK065123 · United States
NIDDK NIH HHS · P01 DK038226 · United States
NIGMS NIH HHS · GM076592 · United States
NIDDK NIH HHS · 2P01DK065123 · United States
NIGMS NIH HHS · R01 GM076592 · United States
NIDDK NIH HHS · P30DK79341-01 · United States
NIDDK NIH HHS · 2P01DK38226 · United States
External Links
PubMed source DOI: 10.1007/s10555-011-9310-3 PMC Full Text View journal details
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