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PMID: 22037552 Published · epublish English Journal Article Research Support, Non-U.S. Gov't

Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.

Nature genetics ·Vol. 43 ·No. 12 ·2011-10-30 ·Pages 1228-31

Yue WH, Wang HF, Sun LD, Tang FL, Liu ZH, Zhang HX, Li WQ, Zhang YL, Zhang Y, Ma CC, Du B, Wang LF, Ren YQ, Yang YF, Hu XF, Wang Y, Deng W, Tan LW, Tan YL, Chen Q, Xu GM, Yang GG, Zuo XB, Yan H, Ruan YY, Lu TL, Han X, Ma XH, Wang Y, Cai LW, Jin C, Zhang HY, Yan J, Mi WF, Yin XY, Ma WB, Liu Q, Kang L, Sun W, Pan CY, Shuang M, Yang FD, Wang CY, Yang JL, Li KQ, Ma X, Li LJ, Yu X, Li QZ, Huang X, Lv LX, Li T, Zhao GP, Huang W, Zhang XJ, Zhang D

Abstract

To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with schizophrenia and 1,599 healthy controls; validation: 4,027 individuals with schizophrenia and 5,603 healthy controls). We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, P(combined) = 4.76 × 10(-11), odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL, P(combined) = 6.91 × 10(-12), OR = 0.78; rs2142731 in an intron of PGBD1, P(combined) = 5.14 × 10(-10), OR = 0.79) and 11p11.2 (rs11038167 near the 5' UTR of TSPAN18, P(combined) = 1.09 × 10(-11), OR = 1.29; rs11038172, P(combined) = 7.21 × 10(-10), OR = 1.25; rs835784, P(combined) = 2.73 × 10(-11), OR = 1.27). These results add to previous evidence of susceptibility loci for schizophrenia at 6p21-p22.1 in the Han Chinese population. We found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain. These findings may lead to new insights into the pathogenesis of schizophrenia.

MeSH Terms
Adult Animals Asians Brain/metabolism Case-Control Studies Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 6 Co-Repressor Proteins/genetics DNA-Binding Proteins/genetics Female Gene Frequency Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Mice Mice, Inbred ICR Nerve Tissue Proteins/genetics Nuclear Proteins/genetics Polymorphism, Single Nucleotide Principal Component Analysis Quantitative Trait Loci Schizophrenia/ethnology,genetics Tetraspanins/genetics Transcription, Genetic
Chemicals
Co-Repressor Proteins DNA-Binding Proteins NKAPL protein, human Nerve Tissue Proteins Nuclear Proteins PGBD1 protein, human TSPAN18 protein, human Tetraspanins ZKSCAN4 protein, human
Authors & Affiliations
56 authors, click to expand affiliations / ORCID
Yue Wei-Hua
Institute of Mental Health, Peking University, Beijing, China.
Wang Hai-Feng
Sun Liang-Dan
Tang Fu-Lei
Liu Zhong-Hua
Zhang Hong-Xing
Li Wen-Qiang
Zhang Yan-Ling
Zhang Yang
Ma Cui-Cui
Du Bo
Wang Li-Fang
Ren Yun-Qing
Yang Yong-Feng
Hu Xiao-Feng
Wang Yi
Deng Wei
Tan Li-Wen
Tan Yun-Long
Chen Qi
Xu Guang-Ming
Yang Gui-Gang
Zuo Xian-bo
Yan Hao
Ruan Yan-Yan
Lu Tian-Lan
Han Xue
Ma Xiao-Hong
Wang Yan
Cai Li-Wei
Jin Chao
Zhang Hong-Yan
Yan Jun
Mi Wei-Feng
Yin Xian-Yong
Ma Wen-Bin
Liu Qi
Kang Lan
Sun Wei
Pan Cheng-Ying
Shuang Mei
Yang Fu-De
Wang Chuan-Yue
Yang Jian-Li
Li Ke-Qing
Ma Xin
Li Ling-Jiang
Yu Xin
Li Qi-Zhai
Huang Xun
Lv Lu-Xian
Li Tao
Zhao Guo-Ping
Huang Wei
Zhang Xue-Jun
Zhang Dai
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Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1546-1718
DOI
10.1038/ng.979
Published
2011-10-30
Epub
2011-00-30
Pages
1228-31
Language
English
Region
United States
NLM ID
9216904
Subset
IM
External Links
PubMed source DOI: 10.1038/ng.979 View journal details
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