Why are proteins O-glycosylated?

Trends in biochemical sciences ·Vol. 15 ·No. 8 ·1990-08-00 ·Pages 291-4

Jentoft N

Abstract

The O-linked oligosaccharides of glycoproteins are usually clustered within heavily glycosylated regions of the peptide chain. Steric interactions between carbohydrate and peptide within these clusters induce the peptide core to adopt a stiff and extended conformation and this conformational effect appears to represent a major function of O-glycosylation.

MeSH Terms

Animals Glycoproteins/metabolism,physiology Glycosylation Protein Conformation

Chemicals

Glycoproteins

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Jentoft N

Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106.

Article Info

Journal

Trends in biochemical sciences

Abbr.

Trends Biochem Sci

ISSN

0968-0004

DOI

10.1016/0968-0004(90)90014-3

Published

1990-08-00

Pages

291-4

Language

English

Region

England

NLM ID

7610674

Subset

Corrections

CommentIn

PMID: 2053132

External Links

PubMed source DOI: 10.1016/0968-0004(90)90014-3 View journal details

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Why are proteins O-glycosylated?

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