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PMID: 22048334 Published · epublish English Journal Article Comment

A novel nuclear miRNA mediated modulation of a non-coding antisense RNA and its cognate sense coding mRNA.

The EMBO journal ·Vol. 30 ·No. 21 ·2011-11-02 ·Pages 4340-1

Rossi JJ

Abstract

暂无摘要

MeSH Terms
Argonaute Proteins/metabolism Humans MicroRNAs/pharmacology RNA/metabolism RNA Cleavage/physiology RNA Interference/drug effects RNA, Antisense/metabolism RNA, Circular
Chemicals
AGO2 protein, human Argonaute Proteins MicroRNAs RNA, Antisense RNA, Circular RNA
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Rossi John J
Department of Molecular and Cellular Biology, Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA. [email protected]
References (10)
10 references, click to expand
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  3. Bidirectional transcription directs both transcriptional gene activation and suppression in human cells.
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  4. Genome-wide natural antisense transcription: coupling its regulation to its different regulatory mechanisms.
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  5. The impact of microRNAs on protein output.
    Nature. 2008 Sep 4;455(7209):64-71 PMID: 18668037
  6. Deep sequencing of human nuclear and cytoplasmic small RNAs reveals an unexpectedly complex subcellular distribution of miRNAs and tRNA 3' trailers.
    PLoS One. 2010 May 14;5(5):e10563 PMID: 20498841
  7. Transcriptional regulation by small RNAs at sequences downstream from 3' gene termini.
    Nat Chem Biol. 2010 Aug;6(8):621-9 PMID: 20581822
  8. Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cells.
    Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12422-7 PMID: 17640892
  9. Small interfering RNA-induced transcriptional gene silencing in human cells.
    Science. 2004 Aug 27;305(5688):1289-92 PMID: 15297624
  10. miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA.
    EMBO J. 2011 Sep 30;30(21):4414-22 PMID: 21964070
Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
1460-2075
DOI
10.1038/emboj.2011.373
Email
[email protected]
Published
2011-11-02
Epub
2011-00-02
Pages
4340-1
Language
English
Region
England
NLM ID
8208664
PMCID
PMC3230383
Subset
IM
Grants
NIAID NIH HHS · R01 AI042552 · United States
Corrections
CommentOn
PMID: 21964070
External Links
PubMed source DOI: 10.1038/emboj.2011.373 PMC Full Text View journal details
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