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PMID: 22087006 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Brassinosteroids inhibit pathogen-associated molecular pattern-triggered immune signaling independent of the receptor kinase BAK1.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 109 ·No. 1 ·2012-01-03 ·Pages 303-8

Albrecht C, Boutrot F, Segonzac C, Schwessinger B, Gimenez-Ibanez S, Chinchilla D, Rathjen JP, de Vries SC, Zipfel C

Abstract

Plants and animals use innate immunity as a first defense against pathogens, a costly yet necessary tradeoff between growth and immunity. In Arabidopsis, the regulatory leucine-rich repeat receptor-like kinase (LRR-RLK) BAK1 combines with the LRR-RLKs FLS2 and EFR in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and the LRR-RLK BRI1 in brassinosteroid (BR)-mediated growth. Therefore, a potential tradeoff between these pathways mediated by BAK1 is often postulated. Here, we show a unidirectional inhibition of FLS2-mediated immune signaling by BR perception. Unexpectedly, this effect occurred downstream or independently of complex formation with BAK1 and associated downstream phosphorylation. Thus, BAK1 is not rate-limiting in these pathways. BRs also inhibited signaling triggered by the BAK1-independent recognition of the fungal PAMP chitin. Our results suggest a general mechanism operative in plants in which BR-mediated growth directly antagonizes innate immune signaling.

MeSH Terms
Arabidopsis/drug effects,enzymology,immunology,microbiology Arabidopsis Proteins/metabolism Brassinosteroids/pharmacology Enzyme Activation/drug effects Flagellin/pharmacology Plant Immunity/drug effects,immunology Protein Kinases/metabolism Protein Serine-Threonine Kinases/metabolism Pseudomonas/drug effects,metabolism Receptors, Pattern Recognition/metabolism Signal Transduction/drug effects,immunology Steroids, Heterocyclic/pharmacology
Chemicals
Arabidopsis Proteins Brassinosteroids Receptors, Pattern Recognition Steroids, Heterocyclic Flagellin Protein Kinases BAK1 protein, Arabidopsis FLS2 protein, Arabidopsis BRI1 protein, Arabidopsis Protein Serine-Threonine Kinases brassinolide
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Albrecht Catherine
Laboratory of Biochemistry, Wageningen University, 6703 HA Wageningen, The Netherlands.
Boutrot Freddy
Segonzac Cécile
Schwessinger Benjamin
Gimenez-Ibanez Selena
Chinchilla Delphine
Rathjen John P
de Vries Sacco C
Zipfel Cyril
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
1091-6490
DOI
10.1073/pnas.1109921108
Published
2012-01-03
Epub
2011-00-15
Pages
303-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC3252947
Subset
IM
Grants
Biotechnology and Biological Sciences Research Council · BB/E017134/1 · United Kingdom
Biotechnology and Biological Sciences Research Council · BB/G024944/1 · United Kingdom
Biotechnology and Biological Sciences Research Council · BB/G024936/1 · United Kingdom
Corrections
CommentIn
PMID: 22198764
External Links
PubMed source DOI: 10.1073/pnas.1109921108 PMC Full Text View journal details
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