Fatty acid stimulation of membrane phosphatidylinositol hydrolysis by brain phosphatidylinositol phosphodiesterase.

The Biochemical journal ·Vol. 178 ·No. 2 ·1979-02-15 ·Pages 497-500

Irvine RF, Letcher AJ, Dawson RM

Abstract

The hydrolysis of membrane-bound phosphatidylinositol in rat liver microsomal fraction by the soluble phosphatidylinositol phosphodiesterase from rat brain was markedly stimulated by oleic acid or arachidonic acid. The stimulation did not require added calcium, although it was abolished by EDTA. Lysophosphatidylcholine also totally suppressed the stimulation. A possible role for the fatty acid content of a membrane in controlling phosphatidylinositol turnover is suggested.

MeSH Terms

Animals Brain/enzymology Cell Membrane/metabolism Fatty Acids/pharmacology Hydrolysis In Vitro Techniques Intracellular Membranes/metabolism Microsomes, Liver/metabolism Phosphatidylinositols/metabolism Phosphoric Diester Hydrolases/metabolism Rats Stimulation, Chemical

Chemicals

Fatty Acids Phosphatidylinositols Phosphoric Diester Hydrolases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Irvine R F

Letcher A J

Dawson R M

References (15)

15 references, click to expand

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1780497

Published

1979-02-15

Pages

497-500

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1186539

Subset

External Links

PubMed source DOI: 10.1042/bj1780497 PMC Full Text View journal details

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Fatty acid stimulation of membrane phosphatidylinositol hydrolysis by brain phosphatidylinositol phosphodiesterase.

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