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PMID: 22138821 Published · epublish English Journal Article Research Support, Non-U.S. Gov't

A linear complexity phasing method for thousands of genomes.

Nature methods ·Vol. 9 ·No. 2 ·2011-12-04 ·Pages 179-81

Delaneau O, Marchini J, Zagury JF

Abstract

Human-disease etiology can be better understood with phase information about diploid sequences. We present a method for estimating haplotypes, using genotype data from unrelated samples or small nuclear families, that leads to improved accuracy and speed compared to several widely used methods. The method, segmented haplotype estimation and imputation tool (SHAPEIT), scales linearly with the number of haplotypes used in each iteration and can be run efficiently on whole chromosomes.

MeSH Terms
Genome Haplotypes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Delaneau Olivier
Laboratoire Génomique, Bioinformatique, et Applications (Equipe d'accueil 4627), Conservatoire National des Arts et Métiers, Paris, France.
Marchini Jonathan
Zagury Jean-François
References (12)
12 references, click to expand
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Article Info
Journal
Nature methods
Abbr.
Nat Methods
ISSN
1548-7105
DOI
10.1038/nmeth.1785
Published
2011-12-04
Epub
2011-00-04
Pages
179-81
Language
English
Region
United States
NLM ID
101215604
Subset
IM
Grants
Wellcome Trust · 090532 · United Kingdom
Medical Research Council · G0801823 · United Kingdom
External Links
PubMed source DOI: 10.1038/nmeth.1785 View journal details
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