Home LiteratureArticle Details
PMID: 2214027 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Heterogeneity and evolution rates of delta virus RNA sequences.

Journal of virology ·Vol. 64 ·No. 11 ·1990-11-00 ·Pages 5594-9

Imazeki F, Omata M, Ohto M

Abstract

To investigate the geographical divergence of delta virus RNA sequences, 868 nucleotides (nt), including the delta antigen-coding region, were determined in isolates from two Japanese patients, M and S, by polymerase chain reaction and direct sequencing and compared with three previously reported nucleotide sequences. The sequence obtained for hepatitis delta virus RNA from patient M was approximately 92% identical to sequences previously obtained for two other strains of hepatitis delta virus, whereas the sequence of hepatitis delta virus RNA obtained from patient S was approximately 81% identical to the previously sequenced strains. This suggests that delta agent in Japan has a heterogeneous origin and the delta virus RNA sequence from Japanese patient S is the most divergent delta virus isolate yet analyzed. To study the evolution rate of delta virus RNA, viral isolates obtained 3 and 4 years apart from each of two patients were also sequenced. It was estimated that the substitution rate of viral RNA was 0.57 x 10(-3) nt per site per year in patient M and 0.64 x 10(-3) nt per site per year in patient S for the delta antigen gene.

MeSH Terms
Amino Acid Sequence Antigens, Viral/genetics Base Sequence Biological Evolution Genes, Viral Hepatitis D/microbiology Hepatitis Delta Virus/genetics Hepatitis delta Antigens Humans Molecular Sequence Data Oligonucleotides Polymerase Chain Reaction RNA, Viral/genetics Time Factors Viral Structural Proteins/genetics
Chemicals
Antigens, Viral Hepatitis delta Antigens Oligonucleotides RNA, Viral Viral Structural Proteins hepatitis delta virus large antigen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Imazeki F
First Department of Medicine, Chiba University School of Medicine, Japan.
Omata M
Ohto M
References (25)
25 references, click to expand
  1. Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers.
    Gut. 1977 Dec;18(12):997-1003 PMID: 75123
  2. Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing.
    Cancer Res. 1990 Feb 15;50(4):1121-4 PMID: 2153451
  3. Sequence relationships among the hemagglutinin genes of 12 subtypes of influenza A virus.
    Proc Natl Acad Sci U S A. 1981 Dec;78(12):7639-43 PMID: 6174976
  4. Rapid evolution of RNA genomes.
    Science. 1982 Mar 26;215(4540):1577-85 PMID: 7041255
  5. Influence of delta infection on severity of hepatitis B.
    Lancet. 1982 Oct 30;2(8305):945-7 PMID: 6127458
  6. The delta agent.
    Hepatology. 1983 Sep-Oct;3(5):729-37 PMID: 6413350
  7. Delta hepatitis agent: structural and antigenic properties of the delta-associated particle.
    Infect Immun. 1984 Mar;43(3):1000-5 PMID: 6698598
  8. Transmission of the hepatitis B virus-associated delta agent to the eastern woodchuck.
    Proc Natl Acad Sci U S A. 1984 Apr;81(7):2208-12 PMID: 6585793
  9. Rates of evolution of the retroviral oncogene of Moloney murine sarcoma virus and of its cellular homologues.
    Proc Natl Acad Sci U S A. 1985 Jun;82(12):4198-201 PMID: 2987967
  10. Evolution of human influenza A viruses over 50 years: rapid, uniform rate of change in NS gene.
    Science. 1986 May 23;232(4753):980-2 PMID: 2939560
  11. Genetic variation in HTLV-III/LAV over time in patients with AIDS or at risk for AIDS.
    Science. 1986 Jun 20;232(4757):1548-53 PMID: 3012778
  12. Structure, sequence and expression of the hepatitis delta (delta) viral genome.
    Nature. 1986 Oct 9-15;323(6088):508-14 PMID: 3762705
  13. The hepatitis delta (delta) virus possesses a circular RNA.
    Nature. 1986 Oct 9-15;323(6088):558-60 PMID: 2429192
  14. Structure and replication of the genome of the hepatitis delta virus.
    Proc Natl Acad Sci U S A. 1986 Nov;83(22):8774-8 PMID: 2430299
  15. Cloning and characterisation of a delta virus cDNA sequence derived from a human source.
    J Med Virol. 1987 Aug;22(4):323-31 PMID: 3625178
  16. Molecular cloning and sequencing of a human hepatitis delta (delta) virus RNA.
    Nature. 1987 Sep 24-30;329(6137):343-6 PMID: 3627276
  17. Genomic heterogeneity of hepatitis B virus in a 54-year-old woman who contracted the infection through materno-fetal transmission.
    Jpn J Exp Med. 1987 Aug;57(4):231-6 PMID: 3430800
  18. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.
    Science. 1988 Jan 29;239(4839):487-91 PMID: 2448875
  19. Molecular cloning of hepatitis delta virus RNA from an infected woodchuck liver: sequence, structure, and applications.
    J Virol. 1988 Jun;62(6):1855-61 PMID: 3367426
  20. Basis of hepatitis delta virus disease?
    Nature. 1989 Sep 14;341(6238):111 PMID: 2779649
  21. Fidelity of DNA polymerases in DNA amplification.
    Proc Natl Acad Sci U S A. 1989 Dec;86(23):9253-7 PMID: 2594764
  22. A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan.
    Nucleic Acids Res. 1989 Dec 25;17(24):10367-72 PMID: 2513560
  23. A specific base transition occurs on replicating hepatitis delta virus RNA.
    J Virol. 1990 Mar;64(3):1021-7 PMID: 2304136
  24. Immunogenic domains of hepatitis delta virus antigen: peptide mapping of epitopes recognized by human and woodchuck antibodies.
    J Virol. 1990 Mar;64(3):1108-16 PMID: 1689390
  25. delta Agent: association of delta antigen with hepatitis B surface antigen and RNA in serum of delta-infected chimpanzees.
    Proc Natl Acad Sci U S A. 1980 Oct;77(10):6124-8 PMID: 6934539
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.64.11.5594-5599.1990
Published
1990-11-00
Pages
5594-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC248612
Subset
IM
Databases
GENBANK
D90190, D90191, D90192, D90193
External Links
PubMed source DOI: 10.1128/JVI.64.11.5594-5599.1990 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2