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PMID: 22172719 Published · ppublish English Comment Journal Article

Targeting liver cancer: first steps toward a miRacle?

Cancer cell ·Vol. 20 ·No. 6 ·2011-12-13 ·Pages 698-9

Schwabe RF, Wang TC

Abstract

In a recent issue of Cell, Iliopoulos and colleagues demonstrate a novel and targetable epigenetic amplification loop in hepatocellular carcinoma involving HNF4α, miR-124, IL6-R, Stat3, miR-24, and miR-629. These results establish microRNAs as novel players in early stages of hepatocarcinogenesis and as potential targets for the treatment of hepatocellular carcinoma.

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schwabe Robert F
Department of Medicine, Columbia University, New York, NY 10032, USA. [email protected]
Wang Timothy C
References (10)
10 references, click to expand
  1. Sorafenib in advanced hepatocellular carcinoma.
    N Engl J Med. 2008 Jul 24;359(4):378-90 PMID: 18650514
  2. MicroRNA expression, survival, and response to interferon in liver cancer.
    N Engl J Med. 2009 Oct 8;361(15):1437-47 PMID: 19812400
  3. Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma.
    Cancer Cell. 2011 Feb 15;19(2):232-43 PMID: 21316602
  4. Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA.
    Nat Cell Biol. 2010 Apr;12(4):390-9 PMID: 20305651
  5. Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis.
    Nat Genet. 2003 Jul;34(3):292-6 PMID: 12808453
  6. Gene expression in fixed tissues and outcome in hepatocellular carcinoma.
    N Engl J Med. 2008 Nov 6;359(19):1995-2004 PMID: 18923165
  7. Hepatocellular carcinoma.
    N Engl J Med. 2011 Sep 22;365(12):1118-27 PMID: 21992124
  8. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production.
    Science. 2007 Jul 6;317(5834):121-4 PMID: 17615358
  9. An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis.
    Cell. 2011 Dec 9;147(6):1233-47 PMID: 22153071
  10. An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation.
    Cell. 2009 Nov 13;139(4):693-706 PMID: 19878981
Article Info
Journal
Cancer cell
Abbr.
Cancer Cell
ISSN
1878-3686
DOI
10.1016/j.ccr.2011.11.021
Email
[email protected]
Published
2011-12-13
Pages
698-9
Language
English
Region
United States
NLM ID
101130617
PMCID
PMC3619204
Grants
NIAAA NIH HHS · R01 AA020211 · United States
NIAAA NIH HHS · R01 AA020211-02 · United States
NCI NIH HHS · U54 CA163111 · United States
NCI NIH HHS · U54 CA163111-01 · United States
Corrections
CommentOn
PMID: 19878981
External Links
PubMed source DOI: 10.1016/j.ccr.2011.11.021 PMC Full Text View journal details
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