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PMID: 22187483 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Regulation of immune responses by prostaglandin E2.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 188 ·No. 1 ·2012-01-01 ·Pages 21-8

Kalinski P

Abstract

PGE(2), an essential homeostatic factor, is also a key mediator of immunopathology in chronic infections and cancer. The impact of PGE(2) reflects the balance between its cyclooxygenase 2-regulated synthesis and 15-hydroxyprostaglandin dehydrogenase-driven degradation and the pattern of expression of PGE(2) receptors. PGE(2) enhances its own production but suppresses acute inflammatory mediators, resulting in its predominance at late/chronic stages of immunity. PGE(2) supports activation of dendritic cells but suppresses their ability to attract naive, memory, and effector T cells. PGE(2) selectively suppresses effector functions of macrophages and neutrophils and the Th1-, CTL-, and NK cell-mediated type 1 immunity, but it promotes Th2, Th17, and regulatory T cell responses. PGE(2) modulates chemokine production, inhibiting the attraction of proinflammatory cells while enhancing local accumulation of regulatory T cells cells and myeloid-derived suppressor cells. Targeting the production, degradation, and responsiveness to PGE(2) provides tools to modulate the patterns of immunity in a wide range of diseases, from autoimmunity to cancer.

MeSH Terms
Animals Autoimmune Diseases/immunology,metabolism CD4-Positive T-Lymphocytes/immunology,metabolism Chemokines/immunology,metabolism Cyclooxygenase 2/immunology,metabolism Dendritic Cells/immunology,metabolism Dinoprostone/immunology,metabolism Humans Immunologic Memory/physiology Inflammation Mediators/immunology,metabolism Killer Cells, Natural/immunology,metabolism Neoplasms/immunology,metabolism
Chemicals
Chemokines Inflammation Mediators Cyclooxygenase 2 PTGS2 protein, human Dinoprostone
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kalinski Pawel
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA. [email protected]
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Article Info
Journal
Journal of immunology (Baltimore, Md. : 1950)
Abbr.
J Immunol
ISSN
1550-6606
DOI
10.4049/jimmunol.1101029
Email
[email protected]
Published
2012-01-01
Pages
21-8
Language
English
Region
United States
NLM ID
2985117R
PMCID
PMC3249979
Subset
IM
Grants
NCI NIH HHS · P50 CA121973-05 · United States
NCI NIH HHS · 1P01CA132714 · United States
NCI NIH HHS · 1P50CA121973 · United States
NCI NIH HHS · P01 CA132714-04 · United States
NCI NIH HHS · P50 CA121973 · United States
NCI NIH HHS · P01 CA132714 · United States
External Links
PubMed source DOI: 10.4049/jimmunol.1101029 PMC Full Text View journal details
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