De novo CNVs in bipolar disorder: recurrent themes or new directions?

Neuron ·Vol. 72 ·No. 6 ·2011-12-22 ·Pages 885-7

Girirajan S, Eichler EE

Abstract

In this issue of Neuron, Malhotra and colleagues report an enrichment of de novo copy number variants in bipolar disorder and schizophrenia when compared with those of controls. The study highlights the importance of a genetic model involving rare and disruptive variants to further our understanding of complex neuropsychiatric traits.

MeSH Terms

Bipolar Disorder/genetics DNA Copy Number Variations/genetics Female Genome-Wide Association Study/methods Humans Male Schizophrenia/genetics

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Girirajan Santhosh

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.

Eichler Evan E

Article Info

Journal

Neuron

Abbr.

Neuron

ISSN

1097-4199

DOI

10.1016/j.neuron.2011.12.008

Published

2011-12-22

Pages

885-7

Language

English

Region

United States

NLM ID

8809320

Subset

Corrections

CommentOn

PMID: 22196331

External Links

PubMed source DOI: 10.1016/j.neuron.2011.12.008 View journal details

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De novo CNVs in bipolar disorder: recurrent themes or new directions?

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