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PMID: 22203829 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Maternal obesity and the early origins of childhood obesity: weighing up the benefits and costs of maternal weight loss in the periconceptional period for the offspring.

Experimental diabetes research ·Vol. 2011 ·2011-00-00 ·Pages 585749

Zhang S, Rattanatray L, Morrison JL, Nicholas LM, Lie S, McMillen IC

Abstract

There is a need to understand the separate or interdependent contributions of maternal prepregnancy BMI, gestational weight gain, glycaemic control, and macronutrient intake on the metabolic outcomes for the offspring. Experimental studies highlight that there may be separate influences of maternal obesity during the periconceptional period and late gestation on the adiposity of the offspring. While a period of dietary restriction in obese mothers may ablate the programming of obesity, it is associated with an activation of the stress axis in the offspring. Thus, maternal obesity may result in epigenetic changes which predict the need for efficient fat storage in postnatal life, while maternal weight loss may lead to epigenetic changes which predict later adversity. Thus, development of dietary interventions for obese mothers during the periconceptional period requires a greater evidence base which allows the effective weighing up of the metabolic benefits and costs for the offspring.

MeSH Terms
Animals Child Diet, Reducing/adverse effects Disease Models, Animal Epigenesis, Genetic/physiology Female Humans Mice Obesity/complications,etiology,physiopathology Overnutrition/complications,physiopathology Pregnancy Pregnancy Complications/physiopathology Prenatal Exposure Delayed Effects/etiology,physiopathology Stress, Physiological/physiology Weight Loss/physiology
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Zhang Song
Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5001, Australia.
Rattanatray Leewen
Morrison Janna L
Nicholas Lisa M
Lie Shervi
McMillen I Caroline
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Article Info
Journal
Experimental diabetes research
Abbr.
Exp Diabetes Res
ISSN
1687-5303
DOI
10.1155/2011/585749
Published
2011-00-00
Epub
2011-00-07
Pages
585749
Language
English
Region
United States
NLM ID
101274844
PMCID
PMC3235715
Subset
IM
External Links
PubMed source DOI: 10.1155/2011/585749 PMC Full Text
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