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PMID: 22245832 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

A new branch on the tree: next-generation sequencing in the study of cancer evolution.

Seminars in cell & developmental biology ·Vol. 23 ·No. 2 ·2012-04-00 ·Pages 237-42

Brosnan JA, Iacobuzio-Donahue CA

Abstract

Cancer is a disease caused by the accumulation of genetic alterations in association with successive waves of clonal expansion. Mapping of the human genome sequence, in conjunction with technical advances in the ability to sequence entire genomes, have provided new insight into the mutational spectra and genetic events associated with clonal evolution of cancer. Moving forward, a clearer understanding of those alterations that undergo positive and negative selection throughout carcinogenesis and leading to metastatic dissemination would provide a boon not only to our understanding of cancer evolution, but to the development of potential targets for therapeutic intervention as well.

MeSH Terms
Abnormal Karyotype Cell Line, Tumor Chromosome Mapping/methods Comparative Genomic Hybridization Genes, Neoplasm Genetic Heterogeneity Genome, Human Genomic Instability Humans Mutation Neoplasm Metastasis/genetics Neoplasms/genetics Selection, Genetic Sequence Analysis, DNA/methods
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Brosnan Jacqueline A
Graduate Program in Pathobiology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Iacobuzio-Donahue Christine A
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Article Info
Journal
Seminars in cell & developmental biology
Abbr.
Semin Cell Dev Biol
ISSN
1096-3634
DOI
10.1016/j.semcdb.2011.12.008
Published
2012-04-00
Epub
2012-00-08
Pages
237-42
Language
English
Region
England
NLM ID
9607332
PMCID
PMC3314157
Subset
IM
Grants
NCI NIH HHS · P50 CA062924-12S1 · United States
NCI NIH HHS · R01 CA140599 · United States
NCI NIH HHS · P50 CA062924-10S1 · United States
NCI NIH HHS · R01 CA140599-04 · United States
NCI NIH HHS · P50 CA62924 · United States
NCI NIH HHS · R01 CA140599-03 · United States
NCI NIH HHS · P50 CA062924-06 · United States
NCI NIH HHS · R01 CA140599-02 · United States
NCI NIH HHS · P50 CA062924-11 · United States
NCI NIH HHS · P50 CA062924-11S1 · United States
NCI NIH HHS · R01 CA140599-01 · United States
NCI NIH HHS · P50 CA062924-09 · United States
NCI NIH HHS · CA140599 · United States
NCI NIH HHS · P50 CA062924 · United States
NCI NIH HHS · P50 CA062924-08 · United States
NCI NIH HHS · P50 CA062924-10 · United States
NCI NIH HHS · P50 CA062924-12 · United States
NCI NIH HHS · P50 CA062924-07 · United States
External Links
PubMed source DOI: 10.1016/j.semcdb.2011.12.008 PMC Full Text View journal details
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