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PMID: 222676 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Polymyxin B sulfate modification of bacterial endotoxin: effects on the development of endotoxin shock in dogs.

Infection and immunity ·Vol. 23 ·No. 3 ·1979-03-00 ·Pages 660-4

From AH, Fong JS, Good RA

Abstract

The effects of endotoxin (lipopolysaccharide [LPS]) on the pathogenesis of canine endotoxin shock were compared with those of LPS which had interacted with polymyxin B sulfate prior to administration. Both LPS and polymyxin B-modified LPS caused comparable early decreases in aortic blood pressure, leukocyte and platelet numbers, and serum complement levels. However, in dogs receiving polymyxin B-modified LPS the late hypotensive phase was significantly ameliorated and lethality was significantly decreased. These data indicate that polymyxin B-modified LPS, though significantly less lethal than unmodified LPS, was capable of major interactions with several components of the humoral defense system, and support the concept that such interactions are not determinative in the pathogenesis of canine endotoxin shock.

MeSH Terms
Animals Blood Pressure/drug effects Complement System Proteins/analysis Disease Models, Animal Dogs Endotoxins/antagonists & inhibitors Escherichia coli Lipopolysaccharides/antagonists & inhibitors Polymyxin B/pharmacology Polymyxins/pharmacology Shock, Septic/etiology
Chemicals
Endotoxins Lipopolysaccharides Polymyxins Complement System Proteins Polymyxin B
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
From A H
Fong J S
Good R A
References (19)
19 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.23.3.660-664.1979
Published
1979-03-00
Pages
660-4
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC414215
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.23.3.660-664.1979 PMC Full Text View journal details
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