Home LiteratureArticle Details
PMID: 22343285 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.

Bakken TE, Roddey JC, Djurovic S, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Gruen JR, Jernigan TL, Kaufmann WE, Kenet T, Kennedy DN, Kuperman JM, Murray SS, Sowell ER, Rimol LM, Mattingsdal M, Melle I, Agartz I, Andreassen OA, Schork NJ, Dale AM, Alzheimer's Disease Neuroimaging Initiative, Pediatric Imaging, Neurocognition, and Genetics Study, Weiner M, Aisen P, Petersen R, Jack CR, Jagust W, Trojanowki JQ, Toga AW, Beckett L, Green RC, Saykin AJ, Morris J, Liu E, Montine T, Gamst A, Thomas RG, Donohue M, Walter S, Gessert D, Sather T, Harvey D, Kornak J, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Bandy D, Koeppe RA, Foster N, Reiman EM, Chen K, Mathis C, Cairns NJ, Taylor-Reinwald L, Trojanowki JQ, Shaw L, Lee VM, Korecka M, Crawford K, Neu S, Foroud TM, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder PJ, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider LS, Pawluczyk S, Spann BM, Brewer J, Vanderswag H, Heidebrink JL, Lord JL, Johnson K, Doody RS, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig LS, Bell KL, Morris JC, Ances B, Carroll M, Leon S, Mintun MA, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah RC, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon MJ, Glodzik L, De Santi S, Doraiswamy PM, Petrella JR, Coleman RE, Arnold SE, Karlawish JH, Wolk D, Smith CD, Jicha G, Hardy P, Lopez OL, Oakley M, Simpson DM, Porsteinsson AP, Goldstein BS, Martin K, Makino KM, Ismail MS, Brand C, Mulnard RA, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey AI, Lah JJ, Cellar JS, Burns JM, Anderson HS, Swerdlow RH, Apostolova L, Lu PH, Bartzokis G, Silverman DH, Graff-Radford NR, Parfitt F, Johnson H, Farlow MR, Hake AM, Matthews BR, Herring S, van Dyck CH, Carson RE, MacAvoy MG, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Ging-Yuek, Hsiung R, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam MM, Lipowski K, Wu CK, Johnson N, Sadowsky C, Martinez W, Villena T, Turner RS, Johnson K, Reynolds B, Sperling RA, Johnson KA, Marshall G, Frey M, Yesavage J, Taylor JL, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson AE, Norbash A, Johnson PL, Obisesan TO, Wolday S, Bwayo SK, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, Kittur S, Borrie M, Lee TY, Bartha R, Johnson S, Asthana S, Carlsson CM, Potkin SG, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre DW, Kataki M, Zimmerman EA, Celmins D, Brown AD, Pearlson GD, Blank K, Anderson K, Santulli RB, Schwartz ES, Sink KM, Williamson JD, Garg P, Watkins F, Ott BR, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen HJ, Miller BL, Mintzer J, Longmire CF, Spicer K, Finger E, Rachinsky I, Drost D, Jernigan T, McCabe C, Grant E, Ernst T, Kuperman J, Chung Y, Murray S, Bloss C, Darst B, Pritchett L, Saito A, Amaral D, DiNino M, Eyngorina B, Sowell E, Houston S, Soderberg L, Kaufmann W, van Zijl P, Rizzo-Busack H, Javid M, Mehta N, Ruberry E, Powers A, Rosen B, Gebhard N, Manigan H, Frazier J, Kennedy D, Yakutis L, Hill M, Gruen J, Bosson-Heenan J, Carlson H

Abstract

Visual cortical surface area varies two- to threefold between human individuals, is highly heritable, and has been correlated with visual acuity and visual perception. However, it is still largely unknown what specific genetic and environmental factors contribute to normal variation in the area of visual cortex. To identify SNPs associated with the proportional surface area of visual cortex, we performed a genome-wide association study followed by replication in two independent cohorts. We identified one SNP (rs6116869) that replicated in both cohorts and had genome-wide significant association (P(combined) = 3.2 × 10(-8)). Furthermore, a metaanalysis of imputed SNPs in this genomic region identified a more significantly associated SNP (rs238295; P = 6.5 × 10(-9)) that was in strong linkage disequilibrium with rs6116869. These SNPs are located within 4 kb of the 5' UTR of GPCPD1, glycerophosphocholine phosphodiesterase GDE1 homolog (Saccharomyces cerevisiae), which in humans, is more highly expressed in occipital cortex compared with the remainder of cortex than 99.9% of genes genome-wide. Based on these findings, we conclude that this common genetic variation contributes to the proportional area of human visual cortex. We suggest that identifying genes that contribute to normal cortical architecture provides a first step to understanding genetic mechanisms that underlie visual perception.

MeSH Terms
Adolescent Adult Aged Brain/pathology Brain Mapping/methods Cohort Studies Diagnostic Imaging/methods Female Genetic Variation Genome-Wide Association Study Genomics Genotype Humans Male Middle Aged Models, Genetic Phosphoric Diester Hydrolases/genetics Polymorphism, Single Nucleotide Saccharomyces cerevisiae/metabolism Visual Cortex/anatomy & histology,pathology
Chemicals
Phosphoric Diester Hydrolases glycerophosphocholine phosphodiesterase glycerophosphodiester phosphodiesterase
Authors & Affiliations
298 authors, click to expand affiliations / ORCID
Bakken Trygve E
Medical Scientist Training Program, University of California at San Diego, La Jolla, CA 92093, USA.
Roddey J Cooper
Djurovic Srdjan
Akshoomoff Natacha
Amaral David G
Bloss Cinnamon S
Casey B J
Chang Linda
Ernst Thomas M
Gruen Jeffrey R
Jernigan Terry L
Kaufmann Walter E
Kenet Tal
Kennedy David N
Kuperman Joshua M
Murray Sarah S
Sowell Elizabeth R
Rimol Lars M
Mattingsdal Morten
Melle Ingrid
Agartz Ingrid
Andreassen Ole A
Schork Nicholas J
Dale Anders M
Alzheimer's Disease Neuroimaging Initiative
Pediatric Imaging, Neurocognition, and Genetics Study
Weiner Michael
Aisen Paul
Petersen Ronald
Jack Clifford R
Jagust William
Trojanowki John Q
Toga Arthur W
Beckett Laurel
Green Robert C
Saykin Andrew J
Morris John
Liu Enchi
Montine Tom
Gamst Anthony
Thomas Ronald G
Donohue Michael
Walter Sarah
Gessert Devon
Sather Tamie
Harvey Danielle
Kornak John
Dale Anders
Bernstein Matthew
Felmlee Joel
Fox Nick
Thompson Paul
Schuff Norbert
Alexander Gene
DeCarli Charles
Bandy Dan
Koeppe Robert A
Foster Norm
Reiman Eric M
Chen Kewei
Mathis Chet
Cairns Nigel J
Taylor-Reinwald Lisa
Trojanowki J Q
Shaw Les
Lee Virginia M Y
Korecka Magdalena
Crawford Karen
Neu Scott
Foroud Tatiana M
Potkin Steven
Shen Li
Kachaturian Zaven
Frank Richard
Snyder Peter J
Molchan Susan
Kaye Jeffrey
Quinn Joseph
Lind Betty
Dolen Sara
Schneider Lon S
Pawluczyk Sonia
Spann Bryan M
Brewer James
Vanderswag Helen
Heidebrink Judith L
Lord Joanne L
Johnson Kris
Doody Rachelle S
Villanueva-Meyer Javier
Chowdhury Munir
Stern Yaakov
Honig Lawrence S
Bell Karen L
Morris John C
Ances Beau
Carroll Maria
Leon Sue
Mintun Mark A
Schneider Stacy
Marson Daniel
Griffith Randall
Clark David
Grossman Hillel
Mitsis Effie
Romirowsky Aliza
deToledo-Morrell Leyla
Shah Raj C
Duara Ranjan
Varon Daniel
Roberts Peggy
Albert Marilyn
Onyike Chiadi
Kielb Stephanie
Rusinek Henry
de Leon Mony J
Glodzik Lidia
De Santi Susan
Doraiswamy P Murali
Petrella Jeffrey R
Coleman R Edward
Arnold Steven E
Karlawish Jason H
Wolk David
Smith Charles D
Jicha Greg
Hardy Peter
Lopez Oscar L
Oakley MaryAnn
Simpson Donna M
Porsteinsson Anton P
Goldstein Bonnie S
Martin Kim
Makino Kelly M
Ismail M Saleem
Brand Connie
Mulnard Ruth A
Thai Gaby
Mc-Adams-Ortiz Catherine
Womack Kyle
Mathews Dana
Quiceno Mary
Diaz-Arrastia Ramon
King Richard
Weiner Myron
Martin-Cook Kristen
DeVous Michael
Levey Allan I
Lah James J
Cellar Janet S
Burns Jeffrey M
Anderson Heather S
Swerdlow Russell H
Apostolova Liana
Lu Po H
Bartzokis George
Silverman Daniel H S
Graff-Radford Neill R
Parfitt Francine
Johnson Heather
Farlow Martin R
Hake Ann Marie
Matthews Brandy R
Herring Scott
van Dyck Christopher H
Carson Richard E
MacAvoy Martha G
Chertkow Howard
Bergman Howard
Hosein Chris
Black Sandra
Stefanovic Bojana
Caldwell Curtis
Ging-Yuek
Hsiung Robin
Feldman Howard
Mudge Benita
Assaly Michele
Kertesz Andrew
Rogers John
Trost Dick
Bernick Charles
Munic Donna
Kerwin Diana
Mesulam Marek-Marsel
Lipowski Kristina
Wu Chuang-Kuo
Johnson Nancy
Sadowsky Carl
Martinez Walter
Villena Teresa
Turner Raymond Scott
Johnson Kathleen
Reynolds Brigid
Sperling Reisa A
Johnson Keith A
Marshall Gad
Frey Meghan
Yesavage Jerome
Taylor Joy L
Lane Barton
Rosen Allyson
Tinklenberg Jared
Sabbagh Marwan
Belden Christine
Jacobson Sandra
Kowall Neil
Killiany Ronald
Budson Andrew E
Norbash Alexander
Johnson Patricia Lynn
Obisesan Thomas O
Wolday Saba
Bwayo Salome K
Lerner Alan
Hudson Leon
Ogrocki Paula
Fletcher Evan
Carmichael Owen
Olichney John
Kittur Smita
Borrie Michael
Lee T-Y
Bartha Rob
Johnson Sterling
Asthana Sanjay
Carlsson Cynthia M
Potkin Steven G
Preda Adrian
Nguyen Dana
Tariot Pierre
Fleisher Adam
Reeder Stephanie
Bates Vernice
Capote Horacio
Rainka Michelle
Scharre Douglas W
Kataki Maria
Zimmerman Earl A
Celmins Dzintra
Brown Alice D
Pearlson Godfrey D
Blank Karen
Anderson Karen
Santulli Robert B
Schwartz Eben S
Sink Kaycee M
Williamson Jeff D
Garg Pradeep
Watkins Franklin
Ott Brian R
Querfurth Henry
Tremont Geoffrey
Salloway Stephen
Malloy Paul
Correia Stephen
Rosen Howard J
Miller Bruce L
Mintzer Jacobo
Longmire Crystal Flynn
Spicer Kenneth
Finger Elizabether
Rachinsky Irina
Drost Dick
Jernigan Terry
McCabe Connor
Grant Ellen
Ernst Thomas
Kuperman Josh
Chung Yoon
Murray Sarah
Bloss Cinnamon
Darst Burcu
Pritchett Lexi
Saito Ashley
Amaral David
DiNino Mishaela
Eyngorina Bella
Sowell Elizabeth
Houston Suzanne
Soderberg Lindsay
Kaufmann Walter
van Zijl Peter
Rizzo-Busack Hilda
Javid Mohsin
Mehta Natasha
Ruberry Erika
Powers Alisa
Rosen Bruce
Gebhard Nitzah
Manigan Holly
Frazier Jean
Kennedy David
Yakutis Lauren
Hill Michael
Gruen Jeffrey
Bosson-Heenan Joan
Carlson Heatherly
References (56)
56 references, click to expand
  1. The basic uniformity in structure of the neocortex.
    Brain. 1980 Jun;103(2):221-44 PMID: 6772266
  2. No major role for the EMX2 gene in schizencephaly.
    Am J Med Genet A. 2008 May 1;146A(9):1142-50 PMID: 18409201
  3. Adaptive evolution of color vision genes in higher primates.
    Science. 1995 Sep 1;269(5228):1265-7 PMID: 7652574
  4. Brain size, head size, and intelligence quotient in monozygotic twins.
    Neurology. 1998 May;50(5):1246-52 PMID: 9595970
  5. Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort.
    J Psychiatr Res. 2010 Sep;44(12):748-53 PMID: 20185149
  6. Germline mutations in the homeobox gene EMX2 in patients with severe schizencephaly.
    Nat Genet. 1996 Jan;12(1):94-6 PMID: 8528262
  7. Brain volumes and surface morphology in monozygotic twins.
    Cereb Cortex. 2002 May;12(5):486-93 PMID: 11950766
  8. Genetic and environmental contributions to regional cortical surface area in humans: a magnetic resonance imaging twin study.
    Cereb Cortex. 2011 Oct;21(10):2313-21 PMID: 21378112
  9. Regulation of area identity in the mammalian neocortex by Emx2 and Pax6.
    Science. 2000 Apr 14;288(5464):344-9 PMID: 10764649
  10. A pediatric twin study of brain morphometry.
    J Child Psychol Psychiatry. 2006 Oct;47(10):987-93 PMID: 17073977
  11. Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers.
    Radiology. 2000 Sep;216(3):672-82 PMID: 10966694
  12. Distinct genetic influences on cortical surface area and cortical thickness.
    Cereb Cortex. 2009 Nov;19(11):2728-35 PMID: 19299253
  13. A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample.
    J Affect Disord. 2010 Oct;126(1-2):312-6 PMID: 20451256
  14. Conserved subcortical and divergent cortical expression of proteins encoded by orthologs of the autism risk gene MET.
    Cereb Cortex. 2011 Jul;21(7):1613-26 PMID: 21127014
  15. Mosaic evolution of brain structure in mammals.
    Nature. 2000 Jun 29;405(6790):1055-8 PMID: 10890446
  16. Genome-wide atlas of gene expression in the adult mouse brain.
    Nature. 2007 Jan 11;445(7124):168-76 PMID: 17151600
  17. Area patterning of the mammalian cortex.
    Neuron. 2007 Oct 25;56(2):252-69 PMID: 17964244
  18. Cortical area size dictates performance at modality-specific behaviors.
    Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4153-8 PMID: 17360492
  19. Polymicrogyria and absence of pineal gland due to PAX6 mutation.
    Ann Neurol. 2003 May;53(5):658-63 PMID: 12731001
  20. Comprehensive EMX2 genotyping of a large schizencephaly case series.
    Am J Med Genet A. 2007 Jun 15;143A(12):1313-6 PMID: 17506092
  21. Interindividual variation in human visual performance.
    J Cogn Neurosci. 1999 Sep;11(5):521-34 PMID: 10511641
  22. High-resolution intersubject averaging and a coordinate system for the cortical surface.
    Hum Brain Mapp. 1999;8(4):272-84 PMID: 10619420
  23. Ecological importance of trichromatic vision to primates.
    Nature. 2001 Mar 15;410(6826):363-6 PMID: 11268211
  24. SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap.
    Bioinformatics. 2008 Dec 15;24(24):2938-9 PMID: 18974171
  25. Hominoid visual brain structure volumes and the position of the lunate sulcus.
    J Hum Evol. 2010 Apr;58(4):281-92 PMID: 20172590
  26. Specification of cerebral cortical areas.
    Science. 1988 Jul 8;241(4862):170-6 PMID: 3291116
  27. Genetic influences on cortical regionalization in the human brain.
    Neuron. 2011 Nov 17;72(4):537-44 PMID: 22099457
  28. A genetic variant that disrupts MET transcription is associated with autism.
    Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16834-9 PMID: 17053076
  29. A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations.
    Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15483-8 PMID: 19717458
  30. Locating the functional and anatomical boundaries of human primary visual cortex.
    Neuroimage. 2009 Jul 15;46(4):915-22 PMID: 19328238
  31. Progressive loss of PAX6, TBR2, NEUROD and TBR1 mRNA gradients correlates with translocation of EMX2 to the cortical plate during human cortical development.
    Eur J Neurosci. 2008 Oct;28(8):1449-56 PMID: 18973570
  32. Cortical surface-based analysis. I. Segmentation and surface reconstruction.
    Neuroimage. 1999 Feb;9(2):179-94 PMID: 9931268
  33. Correlated size variations in human visual cortex, lateral geniculate nucleus, and optic tract.
    J Neurosci. 1997 Apr 15;17(8):2859-68 PMID: 9092607
  34. Cortical magnification within human primary visual cortex correlates with acuity thresholds.
    Neuron. 2003 May 22;38(4):659-71 PMID: 12765616
  35. A twin study of intracerebral volumetric relationships.
    Behav Genet. 2010 Mar;40(2):114-24 PMID: 20112130
  36. Categorical speech representation in human superior temporal gyrus.
    Nat Neurosci. 2010 Nov;13(11):1428-32 PMID: 20890293
  37. Sex-dependent association of common variants of microcephaly genes with brain structure.
    Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):384-8 PMID: 20080800
  38. Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture.
    J Neurosci. 2004 Apr 21;24(16):4030-42 PMID: 15102918
  39. The orphan G protein-coupled receptor, Gpr161, encodes the vacuolated lens locus and controls neurulation and lens development.
    Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2088-93 PMID: 18250320
  40. A number of schizencephaly patients including 2 brothers are heterozygous for germline mutations in the homeobox gene EMX2.
    Eur J Hum Genet. 1997 Jul-Aug;5(4):186-90 PMID: 9359037
  41. Visual field representations and locations of visual areas V1/2/3 in human visual cortex.
    J Vis. 2003;3(10):586-98 PMID: 14640882
  42. Practical aspects of imputation-driven meta-analysis of genome-wide association studies.
    Hum Mol Genet. 2008 Oct 15;17(R2):R122-8 PMID: 18852200
  43. Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    Nature. 2010 Oct 14;467(7317):832-8 PMID: 20881960
  44. A novel glycerophosphodiester phosphodiesterase, GDE5, controls skeletal muscle development via a non-enzymatic mechanism.
    J Biol Chem. 2010 Sep 3;285(36):27652-63 PMID: 20576599
  45. PLINK: a tool set for whole-genome association and population-based linkage analyses.
    Am J Hum Genet. 2007 Sep;81(3):559-75 PMID: 17701901
  46. Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B.
    Nat Genet. 1998 Aug;19(4):366-70 PMID: 9697698
  47. Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity.
    BMC Neurosci. 2005 Mar 17;6:18 PMID: 15774010
  48. Genomic control, a new approach to genetic-based association studies.
    Theor Popul Biol. 2001 Nov;60(3):155-66 PMID: 11855950
  49. PAX6 haploinsufficiency causes cerebral malformation and olfactory dysfunction in humans.
    Nat Genet. 2001 Jul;28(3):214-6 PMID: 11431688
  50. Principal components analysis corrects for stratification in genome-wide association studies.
    Nat Genet. 2006 Aug;38(8):904-9 PMID: 16862161
  51. The surface area of human V1 predicts the subjective experience of object size.
    Nat Neurosci. 2011 Jan;14(1):28-30 PMID: 21131954
  52. How does your cortex grow?
    J Neurosci. 2011 May 11;31(19):7174-7 PMID: 21562281
  53. Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder.
    Biol Psychiatry. 2010 Jul 1;68(1):41-50 PMID: 20609836
  54. Quantitative genetic modeling of variation in human brain morphology.
    Cereb Cortex. 2001 Sep;11(9):816-24 PMID: 11532887
  55. Linked regularities in the development and evolution of mammalian brains.
    Science. 1995 Jun 16;268(5217):1578-84 PMID: 7777856
  56. Recessive LAMC3 mutations cause malformations of occipital cortical development.
    Nat Genet. 2011 Jun;43(6):590-4 PMID: 21572413
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
1091-6490
Published
2012-03-06
Epub
2012-00-16
Pages
3985-90
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC3309762
Subset
IM
Grants
NCATS NIH HHS · UL1 TR000117 · United States
NIA NIH HHS · R01 AG031224 · United States
NIDA NIH HHS · R01 DA030976 · United States
NIDA NIH HHS · U01 DA024417 · United States
NIA NIH HHS · R01 AG012101 · United States
NIMH NIH HHS · P50MH081755 · United States
NIMH NIH HHS · R01 MH080134 · United States
NIMH NIH HHS · N01MH22005 · United States
NIA NIH HHS · R01 AG030474 · United States
NCI NIH HHS · U54CA143906 · United States
NIMH NIH HHS · R01 MH078151 · United States
NIA NIH HHS · R01 AG022374 · United States
NINDS NIH HHS · P50 NS022343 · United States
NIA NIH HHS · U19 AG023122 · United States
NIA NIH HHS · R01 AG013616 · United States
NIA NIH HHS · U01 AG024904 · United States
NIA NIH HHS · U19 AG010483 · United States
NHLBI NIH HHS · R01HL089655 · United States
NIA NIH HHS · P30 AG008051 · United States
NCRR NIH HHS · UL1 RR033173 · United States
NIA NIH HHS · P30 AG013846 · United States
NCRR NIH HHS · UL1 RR025774 · United States
NHLBI NIH HHS · R01 HL089655 · United States
NIDA NIH HHS · R01DA030976 · United States
NIA NIH HHS · R01AG035020 · United States
NIA NIH HHS · R01AG031224 · United States
NICHD NIH HHS · P30 HD004147 · United States
NINDS NIH HHS · U54 NS056883 · United States
NINDS NIH HHS · U54NS056883 · United States
NIMH NIH HHS · R01 MH083320 · United States
NIA NIH HHS · P01 AG019724 · United States
NIA NIH HHS · P50 AG005138 · United States
NIMH NIH HHS · R01MH080134 · United States
NCRR NIH HHS · 5UL1RR025774 · United States
NIMH NIH HHS · P50 MH081755 · United States
NIA NIH HHS · R01 AG035020 · United States
NIA NIH HHS · P30 AG019610 · United States
NIDA NIH HHS · U01DA024417 · United States
NIA NIH HHS · R01AG22381 · United States
NIA NIH HHS · R01AG030474 · United States
NIMH NIH HHS · R01MH078151-01A1 · United States
NIBIB NIH HHS · P41 EB015909 · United States
NINDS NIH HHS · P50NS22343 · United States
NCATS NIH HHS · UL1 TR001998 · United States
NIA NIH HHS · U19AG023122-01 · United States
NIDA NIH HHS · RC2 DA029475 · United States
NIDA NIH HHS · RC2DA029475 · United States
NIA NIH HHS · R01 AG022381 · United States
NCI NIH HHS · U54 CA143906 · United States
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]