Home LiteratureArticle Details
PMID: 22395693 Published · epublish English Letter Research Support, Non-U.S. Gov't Comment

Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system.

Nature medicine ·Vol. 18 ·No. 3 ·2012-03-06 ·Pages 344-6; author reply 346

Ciampricotti M, Hau CS, Doornebal CW, Jonkers J, de Visser KE

Abstract

暂无摘要

MeSH Terms
Animals Antineoplastic Agents/therapeutic use Apoptosis/immunology Calreticulin/immunology Carrier Proteins/immunology,metabolism Colonic Neoplasms/metabolism Dendritic Cells/immunology,metabolism Humans Interleukin-1beta/metabolism Neoplasms/drug therapy,radiotherapy Toll-Like Receptor 4/immunology
Chemicals
Antineoplastic Agents Calreticulin Carrier Proteins Interleukin-1beta Toll-Like Receptor 4
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ciampricotti Metamia
Hau Cheei-Sing
Doornebal Chris W
Jonkers Jos
de Visser Karin E
References (10)
10 references, click to expand
  1. Calreticulin exposure dictates the immunogenicity of cancer cell death.
    Nat Med. 2007 Jan;13(1):54-61 PMID: 17187072
  2. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.
    Science. 2009 Jun 12;324(5933):1457-61 PMID: 19460966
  3. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
    Nat Med. 2009 Oct;15(10):1170-8 PMID: 19767732
  4. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy.
    Cancer Discov. 2011 Jun;1(1):54-67 PMID: 22039576
  5. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.
    Nat Med. 2007 Sep;13(9):1050-9 PMID: 17704786
  6. Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice.
    J Clin Invest. 2010 Apr;120(4):1111-24 PMID: 20234093
  7. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma.
    N Engl J Med. 2011 Jun 30;364(26):2517-26 PMID: 21639810
  8. Pivotal role of innate and adaptive immunity in anthracycline chemotherapy of established tumors.
    Cancer Res. 2011 Jul 15;71(14):4809-20 PMID: 21646474
  9. Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness.
    J Exp Med. 2008 Jul 7;205(7):1687-700 PMID: 18573907
  10. Cancer immunotherapy and preclinical studies: why we are not wasting our time with animal experiments.
    Hematol Oncol Clin North Am. 2006 Jun;20(3):567-84 PMID: 16762725
Article Info
Journal
Nature medicine
Abbr.
Nat Med
ISSN
1546-170X
DOI
10.1038/nm.2652
Published
2012-03-06
Epub
2012-00-06
Pages
344-6; author reply 346
Language
English
Region
United States
NLM ID
9502015
Subset
IM
Grants
Worldwide Cancer Research · 11-0677 · United Kingdom
Corrections
CommentOn
PMID: 17187072
CommentOn
PMID: 17704786
CommentOn
PMID: 19767732
External Links
PubMed source DOI: 10.1038/nm.2652 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2