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PMID: 22397654
Published · ppublish
English
Case Reports
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Immunologic correlates of the abscopal effect in a patient with melanoma.
Abstract
The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). We report a case of the abscopal effect in a patient with melanoma treated with ipilimumab and radiotherapy. Temporal associations were noted: tumor shrinkage with antibody responses to the cancer-testis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibody responses to other antigens after radiotherapy. (Funded by the National Institutes of Health and others.).
MeSH Terms
Adult
Antibodies/blood
Antibodies, Monoclonal/therapeutic use
Combined Modality Therapy
Female
Humans
Ipilimumab
Lung Neoplasms/drug therapy,immunology,radiotherapy,secondary
Melanoma/drug therapy,immunology,radiotherapy,secondary
Neoplasm Metastasis/immunology
Skin Neoplasms/pathology
Chemicals
Antibodies
Antibodies, Monoclonal
Ipilimumab
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Article Info
Journal
The New England journal of medicine
Abbr.
N Engl J Med
ISSN
1533-4406
Published
2012-03-08
Pages
925-31
Language
English
Region
United States
NLM ID
0255562
PMCID
PMC3345206
Subset
IM
Grants
NCI NIH HHS · RC2CA148468 · United States
NCI NIH HHS · R25 CA020449 · United States
NCI NIH HHS · RC2 CA148468 · United States
Howard Hughes Medical Institute · United States
NCI NIH HHS · P30 CA008748 · United States
NCI NIH HHS · R01 CA056821 · United States
NCI NIH HHS · RC2 CA148468-02 · United States
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