Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics.

Archives of general psychiatry ·Vol. 47 ·No. 11 ·1990-11-00 ·Pages 1023-8

Pakkenberg B

Abstract

Using a new and unbiased stereological technique, the total numbers of neuron and glial cells in the mediodorsal thalamic nucleus and the nucleus accumbens were found to be significantly reduced in schizophrenic patients compared with controls. The total neuron and glial cell number in the ventral pallidum and in the basolateral nucleus of amygdala did not differ in the two groups.

MeSH Terms

Adult Aged Amygdala/cytology Cell Count Female Globus Pallidus/cytology Humans Male Middle Aged Neuroglia/cytology Neurons/cytology Nucleus Accumbens/cytology Schizophrenia/diagnosis Thalamic Nuclei/cytology

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Pakkenberg B

Neurological Research Laboratory, Hvidovre Hospital, Copenhagen, Denmark.

Article Info

Journal

Archives of general psychiatry

Abbr.

Arch Gen Psychiatry

ISSN

0003-990X

DOI

10.1001/archpsyc.1990.01810230039007

Published

1990-11-00

Pages

1023-8

Language

English

Region

United States

NLM ID

0372435

Subset

External Links

PubMed source DOI: 10.1001/archpsyc.1990.01810230039007 View journal details

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Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics.

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