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PMID: 22420621 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Exorcising the exocyst complex.

Traffic (Copenhagen, Denmark) ·Vol. 13 ·No. 7 ·2012-07-00 ·Pages 898-907

Heider MR, Munson M

Abstract

The exocyst complex is an evolutionarily conserved multisubunit protein complex implicated in tethering secretory vesicles to the plasma membrane. Originally identified two decades ago in budding yeast, investigations using several different eukaryotic systems have since made great progress toward determination of the overall structure and organization of the eight exocyst subunits. Studies point to a critical role for the complex as a spatiotemporal regulator through the numerous protein and lipid interactions of its subunits, although a molecular understanding of exocyst function has been challenging to elucidate. Recent progress demonstrates that the exocyst is also important for additional trafficking steps and cellular processes beyond exocytosis, with links to development and disease. In this review, we discuss current knowledge of exocyst architecture, assembly, regulation and its roles in a variety of cellular trafficking pathways.

MeSH Terms
Animals Drosophila/metabolism Exocytosis Humans Secretory Pathway Vesicular Transport Proteins/chemistry,metabolism,physiology Yeasts/metabolism
Chemicals
Vesicular Transport Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Heider Margaret R
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Munson Mary
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Article Info
Journal
Traffic (Copenhagen, Denmark)
Abbr.
Traffic
ISSN
1600-0854
DOI
10.1111/j.1600-0854.2012.01353.x
Published
2012-07-00
Epub
2012-00-08
Pages
898-907
Language
English
Region
England
NLM ID
100939340
PMCID
PMC3374049
Subset
IM
Grants
NIGMS NIH HHS · R01 GM068803 · United States
NIGMS NIH HHS · R01 GM068803-08 · United States
NIGMS NIH HHS · GM068803 · United States
External Links
PubMed source DOI: 10.1111/j.1600-0854.2012.01353.x PMC Full Text View journal details
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