The persistence of adriamycin in man and rat.

British journal of clinical pharmacology ·Vol. 1 ·No. 3 ·1974-06-00 ·Pages 241-7

Wilkinson PM, Mawer GE

Abstract

1 Adriamycin was administered as a single intravenous dose. The plasma concentration in man and rat decayed as a double exponential function of time. 2 A two compartment model was used to predict plasma and tissue concentrations in man and the rat. The validity of the tissue concentration predictions was confirmed experimentally in the rat. 3 Tissue components had a high capacity for the drug. There was evidence in the rat of preferential accumulation in the liver, spleen and bone marrow. 4 The large tissue capacity and the prolonged half time for elimination predispose to accumulation. This may be responsible for the greater toxicity of treatment schedules with short intervals between consecutive doses.

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wilkinson P M

Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, and Department of Pharmacology, University of Manchester, Oxford Road, Manchester.

Mawer G E

References (16)

16 references, click to expand

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Article Info

Journal

British journal of clinical pharmacology

Abbr.

Br J Clin Pharmacol

ISSN

0306-5251

DOI

10.1111/j.1365-2125.1974.tb00244.x

Published

1974-06-00

Pages

241-7

Language

English

Region

England

NLM ID

7503323

PMCID

PMC1402555

External Links

PubMed source DOI: 10.1111/j.1365-2125.1974.tb00244.x PMC Full Text View journal details

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The persistence of adriamycin in man and rat.

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