Home LiteratureArticle Details
PMID: 22457924 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Anti-H-2 antibodies induced by syngeneic immunization.

Immunogenetics ·Vol. 10 ·No. 4 ·1980-00-00 ·Pages 319-32

Iványi P, van Mourik P, Breuning M, Melief CJ

Abstract

Abstract. Alloreactive cytotoxic antibodies were induced in BALB/c mice by syngeneic immunization with normal lymphoid cells. Sixteen out of 41 mice produced antibodies with distinct anti-H-2 specificity. Anti-Kk antibodies were present in all positive sera, but the individual sera produced different reactivity patterns when tested on a panel of H-2 haplotypes. Absorption and immunoprecipitation experiments confirmed the H-2 specificity of the syngeneic sera. We hypothesize that virus-modified H-2d structures have triggered alloreactive B-cell clones to produce anti-H-2 antibodies.

MeSH Terms
Animals Antibody Specificity/immunology Antibody-Dependent Cell Cytotoxicity/immunology Antilymphocyte Serum/immunology B-Lymphocytes/immunology Cross Reactions H-2 Antigens/immunology Haplotypes Immunization/methods Isoantibodies/immunology Mice Mice, Inbred BALB C
Chemicals
Antilymphocyte Serum H-2 Antigens Isoantibodies anti-H-2 antibodies
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Iványi P
Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, University of Amsterdam, Amsterdam, The Netherlands.
van Mourik P
Breuning M
Melief C J
References (28)
28 references, click to expand
  1. Exclusive involvement of H-2Db or H-2Kd product in the interaction between T-killer lymphocytes and syngeneic H-2b or H-2d viral lymphomas.
    J Exp Med. 1977 Oct 1;146(4):909-22 PMID: 197198
  2. A syngeneic anti tumor serum recognizing a complex H-2 alloantigen.
    Immunobiology. 1979 Aug;156(1-2):110-20 PMID: 540966
  3. Association of mouse major histocompatibility and Rauscher murine leukaemia virus envelope glycoprotein antigens on leukaemia cells and their recognition by syngeneic virus-immune-cytotoxic T-lymphocytes.
    Scand J Immunol. 1978;8(6):497-508 PMID: 83670
  4. Further evidence for depression of H-2 and Ia-like specificities of foreign haplotypes in mouse tumour cell lines.
    Nature. 1976 Jun 24;261(5562):705-7 PMID: 947087
  5. Histocompatibility-2 system in wild mice. IX. Serological analysis of 13 new B10.W congenic lines.
    Immunogenetics. 1980;10(1):45-65 PMID: 6157643
  6. Identification of murine leukemia viral antigens detected on mouse cells by H-2 alloantisera.
    Eur J Immunol. 1976 Sep;6(9):603-7 PMID: 187431
  7. H-2-like specificities of foreign haplotypes appearing on a mouse sarcoma after vaccinia virus infection.
    Nature. 1976 Jan 22;259(5540):228-30 PMID: 1250351
  8. Individual mice recognize the complex nature of H-2 antigens; unexpected reactions (anti-Kk) in anti-BALB/c-H-2d sera produced in the BALB/c-H-2db mutant.
    Transplant Proc. 1979 Mar;11(1):642-6 PMID: 88092
  9. Immunogenetic and immunochemical studies of H-2 antigens of foreign haplotypes on tumour cells.
    J Immunogenet. 1979 Aug;6(4):263-70 PMID: 93131
  10. Cross-reactivity among the products of three nonallelic H-2 loci, H-2Ld, H-2Dq, and H-2Kk.
    Transplantation. 1979 Oct;28(4):339-42 PMID: 505544
  11. Mutation in a new H-2-associated histocompatibility gene closely linked to H-2D.
    J Exp Med. 1977 Jun 1;145(6):1550-8 PMID: 68094
  12. Derepressed alloantigen in transplacentally induced lung tumor coded for by H-2 linked gene.
    Science. 1976 Oct 29;194(4264):532-3 PMID: 973137
  13. Evidence for an H-2/viral protein complex on the cell surface as the basis for the H-2 restriction of cytotoxicity.
    Nature. 1977 Oct 27;269(5631):808-9 PMID: 73137
  14. Lymphocytotoxic antibodies produced by H-2 allo-immunisation distinguish between MuLV-positive and -negative substrains of the same H-2 haplotype.
    Nature. 1979 Dec 20-27;282(5741):843-5 PMID: 229425
  15. Generation of virus specific cytotoxic T cells in vitro. III. Spleen cells stimulated by viral antigens generate alloreactive cytotoxic T cells.
    Immunobiology. 1979 Aug;156(1-2):83-95 PMID: 232074
  16. Two new recombinant H-2 haplotypes, one of which juxtaposes Kb and Ik alleles.
    J Immunol. 1979 Nov;123(5):1965-9 PMID: 114582
  17. Selective incorporation of H-2 antigenic determinants into Friend virus particles.
    Nature. 1977 Mar 31;266(5601):458-9 PMID: 67564
  18. Murine cytotoxic T-cell response to alphavirus is associated mainly withH- 2D ( k ).
    Immunogenetics. 1978 Dec;7(1):551-61 PMID: 21302107
  19. Unexpected lympho-cytotoxic reactions of anti-H-2 sera on normal lymph-node cells: are they due to altered H-2 structures or anti-viral antibodies?
    J Immunogenet. 1980 Feb;7(1):91-7 PMID: 7373067
  20. Isolation and antigenic characterization of the product of a third polymorphic H-2 locus, H-2L.
    J Immunol. 1978 Oct;121(4):1469-72 PMID: 81236
  21. TheH-2L locus and the system of H-2 specificities.
    Immunogenetics. 1978 Dec;7(1):295-311 PMID: 21302085
  22. Individual mice of one inbred strain produce anti-H-2 and anti-HLA antibodies of different specificities.
    Tissue Antigens. 1978 Jul;12(1):32-8 PMID: 694915
  23. Nonrandom inclusion of H-2K and H-2D antigens in Friend virus particles from mice of various strains.
    J Exp Med. 1978 Feb 1;147(2):340-51 PMID: 624903
  24. Anomalous reactions of mouse alloantisera with cultured tumor cells. II. Cytotoxicity is caused by antibodies to leukemia viruses.
    J Immunol. 1975 Nov;115(5):1261-8 PMID: 170342
  25. Anomalous reactions of mouse alloantisera with cultured tumor cells. I. Demonstration of widespread occurrence using reference typing sera.
    J Immunol. 1975 Nov;115(5):1254-60 PMID: 51886
  26. H-2 mutations: their genetics and effect on immune functions.
    Adv Immunol. 1978;26:55-146 PMID: 358801
  27. Biological significance of alloreactivity: T cells stimulated by Sendai virus-coated syngeneic cells specifically lyse allogeneic target cells.
    Proc Natl Acad Sci U S A. 1978 Oct;75(10):5145-9 PMID: 217013
  28. The firstH- 2 mutant workshop.
    Immunogenetics. 1978 Dec;7(1):279-94 PMID: 21302084
Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF01561582
Published
1980-00-00
Pages
319-32
Language
English
Region
United States
NLM ID
0420404
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01561582 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2