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PMID: 22473396 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Parental infertility, infertility treatment and hepatoblastoma: a report from the Children's Oncology Group.

Human reproduction (Oxford, England) ·Vol. 27 ·No. 6 ·2012-06-00 ·Pages 1649-56

Puumala SE, Ross JA, Feusner JH, Tomlinson GE, Malogolowkin MH, Krailo MD, Spector LG

Abstract

A recent study suggested a markedly increased risk of hepatoblastoma (HB) among children conceived with treatment for infertility. However, it is not clear whether this finding is confounded by the association between HB and low birthweight (LBW). Associations between parental infertility and its treatment and HB were examined using data from a case-control study conducted through the Children's Oncology Group (COG). Telephone interviews were completed for 383 mothers of cases diagnosed with HB at US COG institutions between January 2000 and December 2008 and for 387 mothers of controls recruited through state birth registries. Logistic regression was used to examine possible associations. After adjusting for birthweight and other potential confounders, no significant association was found for any of the measures of parental infertility or its treatment. In HB cases conceived through assisted reproductive technology (ART), 4 of 16 also had Beckwith-Wiedemann syndrome (BWS) compared with 9 of 365 in HB cases without ART. Little evidence of an association between parental infertility or its treatment and HB was found. The relationship found in a previous study could be due to LBW and BWS which are risk factors for HB and also associated with parental infertility and its treatment.

MeSH Terms
Adult Beckwith-Wiedemann Syndrome/epidemiology Birth Weight Case-Control Studies Child Child, Preschool Female Gestational Age Hepatoblastoma/epidemiology,etiology Humans Infant Infant, Low Birth Weight Infant, Newborn Infertility/therapy Liver Neoplasms/epidemiology,etiology Male Pregnancy Premature Birth Reproductive Techniques, Assisted/adverse effects
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Puumala Susan E
Department of Pediatrics, University of South Dakota, Sioux Falls, SD 57104, USA.
Ross Julie A
Feusner James H
Tomlinson Gail E
Malogolowkin Marcio H
Krailo Mark D
Spector Logan G
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Article Info
Journal
Human reproduction (Oxford, England)
Abbr.
Hum Reprod
ISSN
1460-2350
DOI
10.1093/humrep/des109
Published
2012-06-00
Epub
2012-00-03
Pages
1649-56
Language
English
Region
England
NLM ID
8701199
PMCID
PMC3357199
Subset
IM
Grants
NCI NIH HHS · K05 CA157439 · United States
NCI NIH HHS · U10CA98413 · United States
NCI NIH HHS · U10CA98543 · United States
NCI NIH HHS · R01CA111355 · United States
External Links
PubMed source DOI: 10.1093/humrep/des109 PMC Full Text View journal details
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