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PMID: 2249257 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The structural gene coding for thiamin-repressible acid phosphatase in Schizosaccharomyces pombe.

Current genetics ·Vol. 18 ·No. 3 ·1990-10-00 ·Pages 269-72

Yang JW, Schweingruber ME

Abstract

The pho4 gene of the fission yeast Schizosaccharomyces pombe is regulated by thiamin. The nucleotide sequence of this gene is given here and it is shown that it matches the amino acid sequence of thiamin-repressible acid phosphatase, corroborating genetic evidence that pho4 represents the structural gene of this enzyme. The gene codes for a protein of 463 amino acids in length and shows regions of strong similarity with the phosphate-repressible acid phosphatase of Schizosaccharomyces pombe. The enzyme has a cleavable signal sequence 18 amino acids long and carries nine potential N-glycosylation sites.

Related Genes

pho4

MeSH Terms

Acid Phosphatase/antagonists & inhibitors,genetics Amino Acid Sequence Base Sequence Cloning, Molecular Genes, Fungal Molecular Sequence Data Restriction Mapping Schizosaccharomyces/genetics Sequence Homology, Nucleic Acid Thiamine/pharmacology

Chemicals

Acid Phosphatase Thiamine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Yang J W

Institute of General Microbiology, University of Bern, Switzerland.

Schweingruber M E

References (13)

13 references, click to expand

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Article Info

Journal

Current genetics

Abbr.

Curr Genet

ISSN

0172-8083

DOI

10.1007/BF00318392

Published

1990-10-00

Pages

269-72

Language

English

Region

United States

NLM ID

8004904

Subset

External Links

PubMed source DOI: 10.1007/BF00318392 View journal details

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The structural gene coding for thiamin-repressible acid phosphatase in Schizosaccharomyces pombe.

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